Acute and Chronic Tubulointerstitial Nephritis Sergey V. Brodsky Tibor Nadasdy TERMINOLOGY Cellular and fluid exudation in the interstitial tissue was noted by Councilman in 1898, while he studied kidneys of…
Diabetic Nephropathy Jean L. Olson Zoltan G. Laszik DIABETIC NEPHROPATHY Diabetes mellitus (DM) is recognized in two forms, classified as type 1 and type 2 DM (1). Type 1 DM…
Renal Disease Caused by Hypertension Jean L. Olson DEFINITION Hypertension, or increased blood pressure, is a worldwide problem with a prevalence of greater than 1 billion people (1). The Joint…
Glomerular Diseases With Organized Deposits Samy S. Iskandar Guillermo A. Herrera INTRODUCTION AND HISTORICAL BACKGROUND The term glomerular diseases with organized deposits has come into use in the medical literature…
Renal Diseases Associated With Plasma Cell Dyscrasias, Amyloidoses, and Waldenström Macroglobulinemia Guillermo A. Herrera Maria M. Picken HISTORICAL PERSPECTIVE The important historical events more than 150 years ago that brought…
Thrombotic Microangiopathies Zoltan G. Laszik Neeraja Kambham Fred G. Silva Thrombotic microangiopathy (TMA) is the pathologic term for a condition characterized by microvascular changes including thrombosis in association with laboratory…
Renal Disease in Pregnancy Agnes B. Fogo EFFECTS OF NORMAL PREGNANCY ON THE KIDNEY Structural Changes in Pregnancy Pregnancy normally induces changes in kidney function. In some women, complications of…
Anti-Glomerular Basement Membrane Glomerulonephritis and Goodpasture Syndrome J. Charles Jennette Volker Nickeleit BACKGROUND INFORMATION Anti-GBM Disease In 1919, Ernest Goodpasture (1) reported an 18-year-old male patient who developed hemoptysis and…
Pauci-Immune and Antineutrophil Cytoplasmic Autoantibody-Mediated Crescentic Glomerulonephritis and Vasculitis J. Charles Jennette David B. Thomas A landmark publication in 1979 by Stilmant et al. (1) reported that many if not…
Renal Involvement in Polyarteritis Nodosa, Kawasaki Disease, Takayasu Arteritis, and Giant Cell Arteritis J. Charles Jennette Harsharan K. Singh BACKGROUND Nomenclature of Systemic Vasculitis Vasculitis is vessel wall inflammation. Perivascular…
