Uric Acid and the Kidney

Oct 11, 2016 by in NEPHROLOGY Comments Off on Uric Acid and the Kidney

Fig. 26.1 Production and metabolism of uric acid. XO xanthine oxidase, XDH xanthine dehydrogenase, NAD nicotinamide adenine dinucleotide The best known consequence of an elevated uric acid in humans is…

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Other Glomerular Diseases

Oct 11, 2016 by in NEPHROLOGY Comments Off on Other Glomerular Diseases

Fig. 19.1 Collagenofibrotic glomerulopathy (PAS stain). From Ponticelli and Glassock [1]; by permission of Oxford University Press The mechanisms responsible for the deposition of type III collagen in glomeruli are…

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Glomerular Disease in Pregnancy

Oct 11, 2016 by in NEPHROLOGY Comments Off on Glomerular Disease in Pregnancy

  Preeclampsia HELLP syndrome Active lupus nephritis Timing in pregnancy (weeks gestation) After 20 weeks After 20 weeks Any gestational age Complement (C3, C4) Normal Normal May be decreased Thrombocytopenia…

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Monoclonal Immunoglobulin Deposition Disease

Oct 11, 2016 by in NEPHROLOGY Comments Off on Monoclonal Immunoglobulin Deposition Disease

Fig. 20.1 Light chain deposition disease. Glomeruli showing (A) PAS and (B) silver positive mesangial nodules. Note the lobular accentuation of the glomerular tufts. Arrows point to mesangial nodules. (PAS-…

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Plasmapheresis

Oct 11, 2016 by in NEPHROLOGY Comments Off on Plasmapheresis

Fig. 27.1 Standard membrane filtration (a), adsorption (b), and selective filtration (c) systems. (a) Blood is pumped into a biocompatible membrane that allows the filtration of plasma while retaining cellular…

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Acute Interstitial Nephritis

Oct 11, 2016 by in NEPHROLOGY Comments Off on Acute Interstitial Nephritis

Medication-related AIN AIN associated with infections Direct invasion of the kidney Remote infection Idiopathic AIN—TINU syndrome AIN associated with glomerular and systemic diseases With anti-TBM antibodies SLE and MCTD Sarcoid…

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Pathogenesis and Management of ANCA-Associated Vasculitis

Oct 11, 2016 by in NEPHROLOGY Comments Off on Pathogenesis and Management of ANCA-Associated Vasculitis

Fig. 10.1 On ethanol-fixed neutrophils, proteinase-3 (PR3) ANCA cause a characteristic cytoplasmic granular centrally accentuated immunofluorescence pattern, referred as c-ANCA (top), while myeloperoxidase (MPO)-ANCA causes a perinuclear immunofluorescence pattern, referred…

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Focal and Segmental Glomerulosclerosis

Oct 11, 2016 by in NEPHROLOGY Comments Off on Focal and Segmental Glomerulosclerosis

Primary (idiopathic) FSGS Secondary FSGS  Classic (not otherwise specified) variant  Infection  Tip lesion variant  HIV (usually collapsing variant)  Collapsing glomerulopathy variant  Parvovirus B19  Perihilar variant Medication and drug related Familial…

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