Membranoproliferative Glomerulonephritis
Fig. 6.1 MPGN due to chronic infection (shunt nephritis). (a) Light microscopy showing an MPGN pattern of injury (PAS ×40). Immunofluorescence microscopy showing granular capillary wall staining for (b) IgG,…
The Collagen IV Nephropathies
Fig. 18.1 Glomerular capillary wall showing thickening and widening (arrows) with basement membrane splitting and lamellations (basket-weave appearance). Note extensive foot process effacement. (x6000). Courtesy Dr. Sanjeev Sethi, Mayo Clinic…
Thrombotic Microangiopathy Not Associated with the Classic/Idiopathic TTP-HUS
1 Antiphospholipid syndrome 2 Systemic lupus erythematosus 3 Systemic scleroderma 4 Malignant hypertension 5 Pregnancy-HELLP syndrome 6 Drugs 7 Malignancy 8 Solid organ transplant 9 Allogeneic stem cell transplant—ionizing radiation…
Minimal Change Disease in Adults
Fig. 2.1 Electron microscopy of a glomerulus from a renal biopsy of a patient with minimal change disease, showing diffuse foot process effacement (white arrows) and microvillous degenerative changes (black…
Renal Involvement by IgG4-Related Disease
Fig. 17.1 A biopsy of a mass lesion in a 62-year-old man shows an expansile “storiform” interstitial fibrosis with marked interstitial inflammation. A silver stain (upper left panel) highlights tubular…
Childhood Onset Nephrotic Syndrome
93. Baudouin V, Alberti C, Lapeyraque AL, Bensman A, Andre JL, Broux F, et al. Mycophenolate mofetil for steroid-dependent nephrotic syndrome: a phase II Bayesian trial. Pediatr Nephrol. 2012;27(3):389–96.PubMed 94….
General Approach to the Diagnosis and Management of Glomerular Diseases
89. Jayne DR, Gaskin G, Rasmussen N, et al. Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am Soc Nephrol. 2007;18(7):2180–8.PubMedCrossRef 90….
Endocrine Hypertension and Chronic Kidney Disease
Fig. 16.1 Inherited endocrine condition related to mineralocorticoid excess. The picture shows the molecular pathways involved in dysregulation of NaCl homeostasis located in the distalrenal tubules. AME apparent mineralocorticoid excess;…
Preeclampsia: Angiogenic Factors, Blood Pressure, and the Kidney
(1) Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA KeywordsPregnancyHypertensionAngiogenic factorsPlacentalKidneyVEGFImmune mechanismsNitric oxideEndothelin Introduction Preeclampsia (PE) is considered a pregnancy-specific…
Renal Sympathetic Denervation
Fig. 7.1 Practical recommendations for the use of renal denervation in clinical practice according to the European Society of Hypertension. (Reprinted from Schmieder et al. [23]. With permission from Wolters…
