Chapter 4 – Acute Liver Failure in Children
Abstract Pediatric acute liver failure (PALF) is not a single diagnosis. Rather, PALF is a complex, rapidly progressive clinical syndrome that is the final common pathway for many disparate conditions;…
Chapter 3 – Mechanisms of Bile Formation and the Pathogenesis of Cholestasis
Abstract Bile formation and flow is an essential physiological function. Adequate bile flow is necessary for innumerable daily functions including digestion, metabolism, growth, development, toxin elimination and adaptation to liver…
Chapter 2 – Functional Development of the Liver
Abstract The liver attains its highest relative size at about 10% of fetal weight at the ninth week of gestation. Early in gestation the liver is the primary site for…
Chapter 1 – Liver Development
Abstract The essential liver endocrine and exocrine functions require a precise spatial arrangement of the repeated hepatic lobule consisting of the central vein, portal vein, hepatic artery, intrahepatic bile duct…
Future of Liver Transplantation in Children
Introduction Liver transplantation was a dream only a century or so ago. The idea of replacing a diseased organ with a new one was a matter of science fiction. However,…
Challenges for Young People With Liver Disease Including Transition to Adult Services
Long-term outcomes following liver transplantation (LT) are inferior for adolescents and young adults in comparison with younger children and adults. Adolescence is a transitional stage of psychosocial development and a…
Chronic Graft Injury
Introduction Patient and graft survival after pediatric liver transplantation (LT) has improved significantly: children undergoing LT have a patient survival of 79% and graft survival of 63% 10 years post-transplant,…
Prospects for Immune Tolerance
Introduction The extraordinary success of liver transplantation (LT) as a treatment for end-stage liver diseases has resulted in the need to redirect research priorities and clinical resources toward improving the…
Psychosocial Outcomes After Pediatric Liver Transplantation
Introduction Liver transplantation (LT) is a lifesaving treatment for children with end-stage liver disease (ESLD). As immunosuppressive and surgical techniques have improved over time, long-term patient and graft survival rates…
Pediatric Liver Transplantation in Asia
Introduction The history of surgery begins with traditional medicine in India (Ayurveda since 2000 BCE) and China (Yin-Yang since 3000 BCE). Surgery began with the first attempt to control bleeding…
