Liver Retransplantation

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Liver Retransplantation

Incidence and Indications—Early and Late Liver Retransplantation The incidence of graft failure after pediatric liver transplantation has been decreasing with surgical and medical progress, but still reaches 10% to 15%…

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Metabolic Conditions

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Metabolic Conditions

An inherited metabolic disorder is an increasingly common indication for liver transplantation (LT), accounting for more than 15% of pediatric cases worldwide and up to 30% in some specialist centers….

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Alagille Syndrome

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Alagille Syndrome

Introduction Alagille syndrome (ALGS) is a rare multisystem disorder and one of the most frequent inherited causes of cholestatic liver disease in children. Traditionally, ALGS has been characterized by the…

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Gene Therapy

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Gene Therapy

Introduction In recent years, the number of gene therapy (GT) trials targeting the liver have grown significantly, particularly when it comes to gene addition strategies (delivery of cDNA for a…

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Biliary Atresia

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Biliary Atresia

Introduction Biliary atresia is a uniquely perinatal disease that 30 years ago would have been universally fatal. With the development of the palliative Kasai portoenterostomy (Morio Kasai, 1922–2008), along with…

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Cell Transplantation

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Cell Transplantation

Introduction For numerous liver diseases of childhood, liver transplantation (LT) is a lifesaving procedure. However, it requires scarce organs, a highly experienced team to manage the surgical procedure, complications, and…

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