Abstract The irritable bowel syndrome (IBS) may well reflect a neurological problem emerging from disordered neurophysiology in the enteric nervous system (ENS), the central nervous system (CNS), or in both…
Abstract This chapter summarizes the role of epithelial ion (K + , Na + , and Cl − ) channels in the gastrointestinal (GI) tract. Both cAMP- and Ca 2…
Abstract The water-soluble vitamins represent a group of structurally and functionally unrelated compounds that share the common feature of being essential for normal cellular functions, growth, and development. With the…
Abstract The recruitment of leukocytes from peripheral blood into the intestine is required for the maintenance of intestinal health and protection from microbial insult. However, during immune-mediated gastrointestinal conditions (e.g.,…
Abstract Gastrointestinal cancers represent a heterogeneous complex array of disorders and diseases. They may be divided into rare inherited forms and more frequent sporadic forms. There is a critical interplay…
Abstract The Slc9a family of Na + /H + exchangers (NHEs) plays a critical role in neutral sodium absorption in the mammalian intestine as well as other absorptive and secretory…
Abstract The objective of this chapter is to provide an overview of our current understanding of the mechanisms underlying absorption of predominant anions [chloride and short-chain fatty acids (SCFAs)] and…
Abstract Many new insights into the molecular mechanisms of intestinal absorption of calcium, phosphate, and magnesium have been made over the past decade. These include the identification, cloning, and characterization…
Abstract Carbohydrates in the diet are digested in the small intestine to glucose, galactose, and fructose, and these sugars are then absorbed by enterocytes lining the upper third of the…
Abstract Helicobacter pylori induces a persistent inflammatory response within the human stomach, and chronic gastritis is the strongest known risk factor for peptic ulceration and distal gastric cancer. Further, H….
