Serrated Polyps
Serrated Polyps Serrated Adenomas Serrated adenomas constitute 1% to 2% of colorectal adenomas (261,262). Patients range in age from 15 to 88 years, with a mean of 63 years. The…
Aberrant Crypt Foci
Aberrant Crypt Foci Aberrant crypt foci (ACF) constitute putative preneoplastic lesions originally described in experimental animal models of colorectal cancer (253,254,255). ACF have been proposed as intermediate biomarkers in carcinogenesis…
Colon Cancer Prevention
Colon Cancer Prevention Colon cancer prevention strategies fall into three major categories: (a) identification and removal of precursor and early lesions, (b) dietary alterations, and (c) chemoprevention. Disease prevention falls…
Colonic Adenomas and Carcinomas
Colonic Adenomas and Carcinomas Colorectal carcinoma is one of the most common neoplasms affecting individuals living in industrialized nations. Colorectal cancer is the fourth ranking cancer worldwide, accounting for approximately…
Introduction
Introduction The large intestine gives rise to a host of neoplasms. In this chapter we will focus on epithelial neoplasms. Neuroendocrine tumors are covered in Chapter 17, hematologic malignancies in…
Inflammatory Bowel Disease
Inflammatory Bowel Disease Chronic idiopathic inflammatory bowel disease (IBD) includes two chronic gastrointestinal disorders of unknown etiology: Ulcerative colitis (UC) and Crohn disease (CD). The natural history of IBD differs…
Miscellaneous Lesions
Miscellaneous Lesions Torsion of Appendices Epiploica (Epiploic Appendagitis) The appendices epiploica lie along the entire colon from the cecum to the upper part of the rectum. Torsion or vascular thrombosis…
Effects of Surgery and Therapeutic Procedures
Effects of Surgery and Therapeutic Procedures Endoscopic Thermal Injury Endoscopic resection of colorectal polyps is currently a standard practice. In general, the resection margin passes through the submucosa. Less than…
Lesions Presenting as Polyps
Lesions Presenting as Polyps Normally, the dynamic process of cell division is balanced by exfoliation from the luminal surface. If an imbalance occurs, either because of increased replication or decreased…
Endometriosis and Endosalpingiosis
Endometriosis and Endosalpingiosis Colonic involvement occurs in 3% to 34% of women with endometriosis. Patients range in age from 28 to 56 years (609). Recurrent, crampy, mild abdominal pain is…
