One of the first observations of a potential neural control of kidney function was made by Claude Bernard in the middle of the 19th century, who reported a unilateral diuresis…

Many of the mediators and regulators of renal salt reabsorption have been identified from physiologic studies. The manner in which these individual elements function in the context of integrated physiology…

In this chapter we review the transport of ions by the loop of Henle, distal convoluted tubule, the connecting tubule, and the collecting duct. We will place special emphasis on…

Kidney development begins with interactions between the ureteric bud, an epithelial outgrowth of the Wolffian duct, and the surrounding metanephric mesenchyme. These mutually inductive interactions results in formation of the…

The idea that the kidney is an organ needs to be tempered by the realization that it is the nephron that is the organ. Each nephron, as far as we…

Recent years have marked an exciting time in the field of anion channel research. More and more of the molecular identities of the functional anion channel groups have been discovered…

Epithelial Na + channels (ENaCs) have a key role in the regulation of extracellular fluid volume and blood pressure. Over the two decades since the initial characterization of ENaCs at…

The tight regulation of cell growth and division within an organ is essential for the development and maintenance of correct structure and function. Perturbations of renal growth occurring either developmentally…

This chapter reviews the molecular physiology of the NaCl co-transporters, with emphasis on the thick ascending limb of Henle’s loop Na + -Cl − co-transporter and the distal convoluted tubule…

The successful transition from single cells to complex multicellular organisms has required the development of mechanisms for cells to communicate with each other, so as to act in concert during…