Fig. 20.1 Light chain deposition disease. Glomeruli showing (A) PAS and (B) silver positive mesangial nodules. Note the lobular accentuation of the glomerular tufts. Arrows point to mesangial nodules. (PAS-…
Fig. 15.1 Thrombus formation in the kidney of aHUS. (a) Silver-methenamine stained section of a glomerulus of an aHUS patient with microthrombi (white arrow). Black arrow points at RBCs (×40)….
Fig. 27.1 Standard membrane filtration (a), adsorption (b), and selective filtration (c) systems. (a) Blood is pumped into a biocompatible membrane that allows the filtration of plasma while retaining cellular…
Fig. 13.1 Collapsing glomerulopathy seen in HIVAN. Jones-methenamine stain showing collapse of the capillary loops with overlying podocyte hyperplasia (×40) Fig. 13.2 Low-power view of collapsing glomerulopathy in HIVAN. Jones-methenamine…
Medication-related AIN AIN associated with infections Direct invasion of the kidney Remote infection Idiopathic AIN—TINU syndrome AIN associated with glomerular and systemic diseases With anti-TBM antibodies SLE and MCTD Sarcoid…
Primary (idiopathic) FSGS Secondary FSGS Classic (not otherwise specified) variant Infection Tip lesion variant HIV (usually collapsing variant) Collapsing glomerulopathy variant Parvovirus B19 Perihilar variant Medication and drug related Familial…
Fig. 10.1 On ethanol-fixed neutrophils, proteinase-3 (PR3) ANCA cause a characteristic cytoplasmic granular centrally accentuated immunofluorescence pattern, referred as c-ANCA (top), while myeloperoxidase (MPO)-ANCA causes a perinuclear immunofluorescence pattern, referred…
Fig. 6.1 MPGN due to chronic infection (shunt nephritis). (a) Light microscopy showing an MPGN pattern of injury (PAS ×40). Immunofluorescence microscopy showing granular capillary wall staining for (b) IgG,…
Fig. 18.1 Glomerular capillary wall showing thickening and widening (arrows) with basement membrane splitting and lamellations (basket-weave appearance). Note extensive foot process effacement. (x6000). Courtesy Dr. Sanjeev Sethi, Mayo Clinic…
1 Antiphospholipid syndrome 2 Systemic lupus erythematosus 3 Systemic scleroderma 4 Malignant hypertension 5 Pregnancy-HELLP syndrome 6 Drugs 7 Malignancy 8 Solid organ transplant 9 Allogeneic stem cell transplant—ionizing radiation…
