A vast majority of ulcers of the stomach and duodenum are due to H pylori infection or nonsteroidal anti-inflammatory drug (NSAID) usage. In patients with apparent H pylori negative NSAID…
Nonsteroidal anti-inflammatory drug (NSAID)-associated intestinal damage to the small and/or large bowel is frequent and may be present in up to 60% to 70% of patients taking these drugs long…
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for treatment of pain and inflammation, despite their association with gastrointestinal complications, including bleeding and perforation. Inhibition of cyclooxygenases (COXs), is the main…
Increasing use of antiplatelet therapies is associated with increasing GI complications, such as ulceration and GI bleeding. Identification of high-risk patients and, in such patients, incorporation of strategies to reduce…
Refractory peptic ulcer disease (PUD) manifests as either hemorrhagic complications (persistent or recurrent bleeding) or gastrointestinal (GI) complications (perforation, stricture, obstruction). Treatment strategies for hemorrhagic complications include Endoscopic therapy, surgery,…
Stress-ulcer bleeding in critically ill patients develops as a result of various risk factors, notably prolonged mechanical ventilation and coagulopathy. The incidence of clinically significant bleeding is decreasing secondary to…
Acute upper gastrointestinal (GI) hemorrhage is one of the commonest causes for hospitalization worldwide. Endoscopic therapy is effective in achieving primary hemostasis. The shift of management from the operating theater…
Managing massive bleeding from a peptic ulcer remains a challenge, and it should involve a multidisciplinary team. Endoscopy is the first-line treatment. Even with larger ulcers, endoscopic hemostasis can be…
This article summarizes and appraises the evidence from randomized controlled trials (RCT) and meta-analyses of RCTs on the role of proton pump inhibitors (PPIs) in non-variceal upper gastrointestinal bleeding, with…
Gastrointestinal (GI) manifestations in older adults can be caused or alleviated by drug therapy. GI medications, such as proton pump inhibitors and histamine-2 receptor antagonists, are among the most commonly…
