This article examines the role of combined-modality therapy for treating locally advanced esophageal cancer. Although surgery remains a cornerstone of treatment, recent studies have demonstrated that pre- or perioperative chemotherapy…
Esophageal malignancy is a major source of morbidity and mortality, despite the recently increased attention to screening and early detection. Prognosis for esophageal cancer remains grim, with advanced tumor stage…
The effort to improve outcomes in esophageal cancer has included attempts at improving staging and patient selection. 2-Deoxy-2-[ 18 F]fluoro-Dglucose positron emission tomography (FDG-PET) has been extensively studied in this context…
Investigations into inherited genetic variations in the DNA code (known as polymorphisms) in the field of oncology have provided preliminary support for an association with cancer risks and outcomes. Early…
This article reviews the environmental risk factors and predisposing conditions for the two main histologic types of esophageal cancer. Tobacco smoking, excessive alcohol consumption, drinking maté, low intake of fresh…
The epidemiology of esophageal cancer has radically changed in the last fifty-years in the Western world. Changes in the predominant type of squamous cell carcinoma to adenocarcinoma, disparities between different…
The history of esophageal cancer dates back to ancient Egyptian times, circa 3000 bc . Since then, the progress in the diagnosis and treatment of esophageal cancer has been steady….
Philip G. McManis, MD I would like to dedicate this issue of the Gastroenterology Clinics of North America to a colleague, Associate Professor Philip G. McManis, MD, who died peacefully…
The recognition that nonsteroidal anti-inflammatory drugs (NSAIDs) increase not only gastrointestinal (GI) but cardiovascular (CV) adverse events as well has created a dilemma for practicing physicians. Clinicians selecting appropriate NSAID…
Despite improved understanding of peptic ulcer disease (PUD) pathogenesis, advances in diagnostic modalities, and the availability of modern pharmalogical, endoscopic and surgical treatments, gastroduodenal ulcer remains a major cause of…
