Fig. 7.1 Skin histology. Cryoglobulinemic vasculitis with fibrinoid necrosis of the capillary walls with pyknotic nuclei and nuclear debris of granulocytes and mononuclear cell infiltrates Rheumatologic Manifestations. Arthralgias, usually bilateral…
Anti-GBM disease ANCA-associated vasculitis • May present with rapidly progressive renal failure and anuria • Systemic prodromal symptoms are uncommon • Dialysis dependency at presentation rarely associated with renal recovery…
Fig. 11.1 The pathogenesis of lupus nephritis and novel therapies based on pathogenic pathways. In this model lupus nephritis begins with the accumulation of autoreactive self-antigens such as nucleosomes. The…
Fig. 14.1 Renal biopsy showing a large cell with CMV inclusions and surrounding interstitial inflammation (H&E, 60×) Fig. 14.2 Immunohistochemistry (immunoperoxidase staining) showing CMV-infected cells Other Immunocompromised Hosts Besides renal…
Fig. 5.1 Representative light microscopy showing thickened glomerular basement membranes with spikes and pinholes (arrows) on higher power. (a) PAS stain, 40×; (b) PAS 60×; (c) Silver stain 60×; (d)…
Fig. 26.1 Production and metabolism of uric acid. XO xanthine oxidase, XDH xanthine dehydrogenase, NAD nicotinamide adenine dinucleotide The best known consequence of an elevated uric acid in humans is…
Fig. 19.1 Collagenofibrotic glomerulopathy (PAS stain). From Ponticelli and Glassock [1]; by permission of Oxford University Press The mechanisms responsible for the deposition of type III collagen in glomeruli are…
Preeclampsia HELLP syndrome Active lupus nephritis Timing in pregnancy (weeks gestation) After 20 weeks After 20 weeks Any gestational age Complement (C3, C4) Normal Normal May be decreased Thrombocytopenia…
Fig. 20.1 Light chain deposition disease. Glomeruli showing (A) PAS and (B) silver positive mesangial nodules. Note the lobular accentuation of the glomerular tufts. Arrows point to mesangial nodules. (PAS-…
Fig. 15.1 Thrombus formation in the kidney of aHUS. (a) Silver-methenamine stained section of a glomerulus of an aHUS patient with microthrombi (white arrow). Black arrow points at RBCs (×40)….
