Fig. 8.1 Computed tomography scan of a locally advanced tumor (a) prior to chemotherapy and (b) following chemotherapy and SBRT to 33 Gy in 5 fractions. Patient then underwent a…
Fig. 11.1 Computed tomography scan of patient with BRPC due to hepatic arterial involvement both before (a) and after (b) neoadjuvant therapy with FOLFIRINOX. The tumor can be seen encasing…
Response criteria Groups Definition Advantages Disadvantages References Radiologic RECIST Complete response Disappearance – Objective, well-evaluated response measure in solid tumors – Not well established in BRCP and LAPC [12] Partial…
Reference BRPC cases Regiment Number resected (%) R0 resection (%) OS, all pts (mo) OS, resected pts (mo) Turrini [85] 49 5-FU/Cis + XRT 9 b b b Chun [24] 74 5-FU/Gem + XRT…
Fig. 10.1 Development of new drugs and regimens in the treatment of pancreatic cancer. Drugs or regimen activity demonstrated in a phase III study. Not all agents are approved by…
Setting Study Regimen Goal Opened Borderline resectable ALLIANCE A021101 mFFX—no 5FU bolus—4 cycles, then RT/cape; gemcit postop Accrual rate, toxicity, CR/PR, completion of all therapy, R0/R1 March 2013 Pilot study…
Fig. 10.1 Pelvic exenteration Differently to the classic VRAM flap, its variants — the de la Plaza, and Taylor flaps, with a skin island designed differently and higher on the…
Fig. 7.1 Operative view after completion of extended (cylindrical) abdominoperineal resection 7.2 Role of Surgery Obtaining a radical R0 resection is the most important prognostic factor related to improved oncologic…
Study N. of patients Indication (%) Mäkelä et al. [16] 106 9 Bleeker et al. [17] 213 33 Primrose et al. [18] 1202 25 Nakamoto et al. [19] 12 58…
Authors Classification Definition Pilipshen et al. (1984) [15] Anatomic pelvic side involved Anastomotic Perianastomotic Pelvic disease without fixation Pelvic disease with fixation Pelvic disease (with or without fixation) presenting through…
