Abdominal Key

Recent years have marked an exciting time in the field of anion channel research. More and more of the molecular identities of the functional anion channel groups have been discovered…

Epithelial Na + channels (ENaCs) have a key role in the regulation of extracellular fluid volume and blood pressure. Over the two decades since the initial characterization of ENaCs at…

The tight regulation of cell growth and division within an organ is essential for the development and maintenance of correct structure and function. Perturbations of renal growth occurring either developmentally…

This chapter reviews the molecular physiology of the NaCl co-transporters, with emphasis on the thick ascending limb of Henle’s loop Na + -Cl − co-transporter and the distal convoluted tubule…

The successful transition from single cells to complex multicellular organisms has required the development of mechanisms for cells to communicate with each other, so as to act in concert during…

The adult kidney functions to keep the organism in a steady state and protect against changes in the volume and composition of the extracellular fluid. Unlike the adult, the neonate…

Increasing evidence suggests that the ATP/P2 receptor system acts in an autocrine or paracrine fashion to affect various aspects of renal function. P2 receptors have been identified in most renal…

Among all of the capillaries in the body, the glomerulus is arguably the most unusual and important, if not the most aesthetically interesting. In this chapter, we review the morphogenesis…

Perhaps nothing underscores the special relationship between the kidney and the eicosanoids better than the profound clinical effects non-steroidal anti-inflammatory drugs (NSAIDS) have on kidney function. NSAIDs are widely used…

Exchange through microvascular walls is both the initial and the final step of transport of materials by the circulation. In most tissues, microvascular exchange is a passive process, driven by…