The Liver in Metabolic Disease
1. Nonimmune fetal hydrops 2. Antecedent history in a newborn infant of pregnancy complications such as HELLP 3. syndrome or fatty liver of pregnancy 3. Unexpected deterioration and death of…
Colitis in Infancy and Childhood
Eosinophilic Allergic proctocolitis Parasitic infection Ischemic Necrotizing enterocolitis Henoch-Schonlein purpura Hemolytic-uremic syndrome Hirschsprung-associated enterocolitis (late) Neutropenic colitis Acute Infections Hirschsprung-associated enterocolitis (early) Pseudomembranous Antibiotic associated (C. difficile) Other infections Hirschsprung-associated…
Polyps and Tumors of the Gastrointestinal Tract in Childhood
Series Time period Age range Total number of tumors Gastrointestinal tumors Finnish Cancer Registry (Teppo et al. 1975) 1953–1970 0–15 2,605 33 intestinal cancers, site not specified, 15 of these…
Enteropathies Associated with Chronic Diarrhea and Malabsorption in Childhood
Neonate Infant Child I Congenital transport and enzymatic deficiencies (A) Carbohydrates Glucose–galactose malabsorption Disaccharidase deficiency Trehalase deficiency Congenital lactase deficiency Sucrase–isomaltase deficiency Fructose malabsorption (B) Lipids Abetalipoproteinemia/hypobetalipoproteinemia Chylomicron retention…
Intestinal Motor Disorders
Usual presentationa Disorder Additional clinical features Inheritance Prenatal/neonatal Megacystis-microcolon hypoperistalsis syndrome Markedly enlarged bladder, intestinal malrotation, short dysmotile colon; females more common than males Probably autosomal recessive Hirschsprung disease 20…
GI and Liver Transplantation Pathology in Childhood
1. Cholestatic disease (a) EHBA 33.6 % (b) Alagille and nonsyndromic paucity 4.6 % (c) Sclerosing cholangitis 1.3 % (d) Familial cholestasis 2.5 % (e) Choledochal cyst 0.3 % (f)…
Diseases of the Biliary Tree
Neonatal hepatitis Cholestatic syndromes Peroxisomal disorders Idiopathic NH PFIC Zellweger Viral NH Type 1 Byler P-type ATPase Infantile Refsum CMV Type 2 canalicular Bile Acid Tx Other enzymopathies Herpes Type…
Hepatitis and Liver Failure in Infancy and Childhood
Histologic features Neonatal hepatitis Obstruction Giant-cell transformation Usually diffuse Usually focal Lobular disarray Usually marked Usually mild Bile duct proliferation Usually absent, focal ductular reaction can be present Prominent and…
Normal and Abnormal Liver Development
Fig. 9.1 Liver development. (a) 30-day embryo. The caudal portion of the hepatic diverticulum (HD) forms the extrahepatic biliary tree (green), while the cranial portion penetrates the septum transversum and…
Gastritis and Gastropathies of Childhood
Fig. 3.1 Cardia in a normal child (alcian blue PAS at pH 2.5). Notice that the surface columnar cells have a mixed staining pattern of magenta and blue indicating presence…
