Palliative Operations for Unresectable Pancreatic Cancer
Author Year N Technical success (%) Morbidity (%) Mortality (%) Recurrence (%) Stent Surgery Stent Surgery Stent Surgery Stent Surgery Bornman et al. 1986 50 84 76 28 32 8…
Stereotactic Body Radiation Therapy as an Emerging Option for Localized Pancreatic Cancer
Fig. 8.1 Computed tomography scan of a locally advanced tumor (a) prior to chemotherapy and (b) following chemotherapy and SBRT to 33 Gy in 5 fractions. Patient then underwent a…
Operative Principles in Managing Patients with Borderline Resectable Pancreas Cancer
Fig. 11.1 Computed tomography scan of patient with BRPC due to hepatic arterial involvement both before (a) and after (b) neoadjuvant therapy with FOLFIRINOX. The tumor can be seen encasing…
Assessment of Response to Preoperative Therapy
Response criteria Groups Definition Advantages Disadvantages References Radiologic RECIST Complete response Disappearance – Objective, well-evaluated response measure in solid tumors – Not well established in BRCP and LAPC [12] Partial…
Role of Systemic Therapy
Reference BRPC cases Regiment Number resected (%) R0 resection (%) OS, all pts (mo) OS, resected pts (mo) Turrini [85] 49 5-FU/Cis + XRT 9 b b b Chun [24] 74 5-FU/Gem + XRT…
Emerging Systemic and Targeted Therapies
Fig. 10.1 Development of new drugs and regimens in the treatment of pancreatic cancer. Drugs or regimen activity demonstrated in a phase III study. Not all agents are approved by…
Overview of Multimodality Therapy
Setting Study Regimen Goal Opened Borderline resectable ALLIANCE A021101 mFFX—no 5FU bolus—4 cycles, then RT/cape; gemcit postop Accrual rate, toxicity, CR/PR, completion of all therapy, R0/R1 March 2013 Pilot study…
Transpelvic Rectus Abdominis Flap Reconstruction Following Abdominoperineal Resection
Fig. 10.1 Pelvic exenteration Differently to the classic VRAM flap, its variants — the de la Plaza, and Taylor flaps, with a skin island designed differently and higher on the…
Indications for Surgery and Surgical Techniques
Fig. 7.1 Operative view after completion of extended (cylindrical) abdominoperineal resection 7.2 Role of Surgery Obtaining a radical R0 resection is the most important prognostic factor related to improved oncologic…
Imaging Modalities
Study N. of patients Indication (%) Mäkelä et al. [16] 106 9 Bleeker et al. [17] 213 33 Primrose et al. [18] 1202 25 Nakamoto et al. [19] 12 58…
