Hirschsprung Disease
Short segment 74–89 % Long segment 12–22 % Total colon 4–13 % Small bowel 3–5 % Clinical Presentation HSCR is debilitating and can be fatal. Clinical presentation is highly variable…
Gastric Motor Disorders
Fig. 23.1 Gastric emptying scan showing delayed gastric emptying with greater than 60 % and 10 % Tc 99 m sulfur colloid activity in the stomach at 2 h and…
Other Esophageal Motility Disorders
Method of treatment Associated disorders Advantages Disadvantages Success Acid suppression DES, NE, NEMDs, SSc Relieves GERD symptoms May only treat GERD symptoms Low success in children Antibiotics Caustic ingestion, CIIP,…
Swallowing and Oropharyngeal Disorders
Signs and symptoms • Coughing, choking, gagging with or after feeds • Wheezing, noisy or wet breathing • Blue spells, apneas, bradycardias • Feeding refusal, arching during feeds • Voice changes • Tearing and red eyes…
Allergy and Neurogastroenterology
• Personal history of atopic disease especially occurring early in life (under 6 months of age) • Family history of atopic disease in parents or siblings • Presenting symptoms and signs indicative of…
Genetics of Motility Disorders: Gastroesophageal Reflux, Triple A Syndrome, Hirschsprung Disease, and Chronic Intestinal Pseudo-obstruction
Refluxate toxicity Gastric acid secretion Duodenogastric reflux Intrinsic gastric volume and pressure Gastric compliance Gastric emptying Gastric acid volume secretion Extrinsic pressure on gastric contents Weight (obesity) Somatic motor tone…
Integration of Biomedical and Psychosocial Issues in Pediatric Functional Gastrointestinal and Motility Disorders
© Springer International Publishing Switzerland 2017Christophe Faure, Nikhil Thapar and Carlo Di Lorenzo (eds.)Pediatric Neurogastroenterology10.1007/978-3-319-43268-7_6 6. Integration of Biomedical and Psychosocial Issues in Pediatric Functional Gastrointestinal and Motility Disorders Miranda A. L. van Tilburg1 (1) Division of Gastroenterology and Hepatology,…
Bile Acids and Gallstones: Epidemiology, Pathogenesis, Diagnosis, and Management
Gallbladder stones CBD stones Cholesterol stone (%) 58.3 31.1 Bilirubin stone Black pigment stone (%) 23.7 11.8 Brown pigment stone (%) 15.9 54.3 Others (%) 2.1 2.8 6.3 Cholesterol…
Bile Acid as Therapeutic Agents
Fig. 5.1 Molecular diagram of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (UDCA), nor-ursodeoxycholic acid (NorUDCA), obeticholic acid (OCA), INT-777, cholestyramine, colestipol, colesevelam-HCl, colestimide, and ezetimibe Approximately 90–95% of bile acids (except…
Bile Acids and Cholestatic Liver Disease 2: Primary Sclerosing Cholangitis
Fig. 8.1 Etiology of PSC Three ulcerative colitis (UC) susceptibility loci associated with PSC, harboring the putative candidate genes REL, IL2, and CARD9, have been identified [6]. A study reported…
