Abstract Drug-induced liver disease has been regarded as rare in children. Large surveys have generally failed to detect drug hepatotoxicity as a major problem in children [1], although adverse drug…
Abstract The liver plays an important role in the immune defense because of its central position adjacent to the gastrointestinal tract, representing the first line of defense against ingested or…
Abstract Liver disease due to inborn errors of metabolism (IEM) is relatively common, and this group of disorders is recognized with increasing frequency as a cause of disease at every…
Abstract Primary sclerosing cholangitis (PSC) is an idiopathic progressive fibrosing cholangiopathy characterized by chronic inflammation and injury of the intra- and/or extrahepatic bile ducts, leading to fibrosis and cholestasis. Although…
Abstract The hepatic rudiment appears at approximately day 18 of gestation in the human embryo. By day 25 it can be recognized as an endodermal diverticulum, which projects into the…
Abstract Hepatitis B virus (HBV) infection continues to be a major global health problem [1]. HBV infection may cause acute, fulminant, or chronic hepatitis, cirrhosis and liver cancer. Although complications…
Abstract Alagille syndrome (ALGS) is an autosomal dominant, multisystem disorder which was first described in 1969 by Daniel Alagille as a constellation of clinical features in five different organ systems…
Abstract Hepatitis C virus (HCV) is an important cause of viral hepatitis in children and the actual number of infected children is clearly underestimated. HCV infection across the pediatric age…
Abstract Autoimmune hepatitis (AIH) is a progressive inflammatory disorder of unknown etiology, characterized histologically by interface hepatitis, serologically by the presence of non-organ specific autoantibodies, biochemically by elevated aminotransferases and…
Abstract Optimal care of children with viral hepatitis necessitates incorporation of recent advances in diagnosis, prevention, and treatment into clinical practice. Although primary viral infection of the liver has been…
