The Cell Cycle
Abstract The cell cycle is a process in which a cell first duplicates its genetic information and then divides to give rise to two daughter cells. To avoid mis-segregation of…
Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
Abstract The mechanisms that orchestrate the development of a multicellular organism from a single common ancestor cell have fascinated people for centuries. We are still a long way from truly…
Notch Pathway Regulation of Intestinal Cell Fate
Abstract The Notch signaling pathway is a key regulator of the intestinal epithelium, playing a fundamental role in stem cell maintenance, progenitor cell proliferation, and cell fate determination. Notch controls…
The Role of Hippo Signaling in Intestinal Homeostasis
Abstract The intestine is the central tissue for digestion and absorption of nutrients. Moreover, the intestine provides tight functional barrier from the vast commensal bacteria that reside in the intestinal…
WNT Signaling in the Intestine: Development, Homeostasis, Disease
Abstract The intestine is a complex organ that has evolved to maximize the luminal surface area for the purpose of absorbing nutrients. The epithelial lining of the intestine must maintain…
Growth Factors in the Intestinal Tract
Abstract Gastrointestinal (GI) tissues express a multitude of growth factors, broadly defined as naturally occurring polypeptides that elicit cellular growth, proliferation, or differentiation following binding to surface membrane receptors. In…
Gastrointestinal Hormones
Abstract Gut peptides are key signaling molecules for the feedback control of gastrointestinal function and the coordination of central and peripheral responses to nutrient ingestion. Peptides are implicated in roles…
Transcription and Epigenetic Regulation
Abstract This chapter covers the broad field of transcription and epigenetic regulatory mechanisms to equip the gastrointestinal physiologist with the tools to understand gene expression. This chapter reviews the composition…
Inherited Disorders of Calcium, Phosphate, and Magnesium
Abstract Calcium, phosphate, and magnesium are important components of cell structure, energy metabolism, and signal transduction and are required for enzymatic activity. All of these minerals are important components of…
Congenital Urinary Tract Obstruction—Diagnosis and Management in the Fetus
Abstract Congenital urinary tract obstruction is commonly detected by routine antenatal ultrasound screening during pregnancy. Obstruction can occur anywhere along the course of the developing urinary tract, can be evident…
