Fig. 1 Platelet COX-1 mechanism of colon tumorigenesis. Platelets may play an early role in colon tumorigenesis through the release of soluble factors and/or microparticles and exosomes), which can activate stromal…
(1) Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, Oxford, OX39DU, UK 1 Introduction 2 Aspirin in Prevention of Colorectal Cancer 2.1 Observational Studies 2.2…
Syndrome Features and inheritance pattern Gene Familial adenomatous polyposis Over 100 adenomatous polyps in colorectum, onset in teens Gastric polyps Congenital Hypertrophy of the Retinal Pigment Epithelium Jaw cysts Desmoid…
Fig. 1 Chemical structures of coxibs. Rofecoxib and etoricoxib, celecoxib, and valdecoxib are diaryleterocyclic derivatives containing a phenylsulphone and a phenylsulphonamide moiety, respectively. Parecoxib is the water soluble and injectable prodrug…
Carboxylic acids Pyrazoles Oxicams COX-2 selective Salicylates Acetic acids Propionic acids Fenamates Acetylsalicylic acid salsalate diflunisal fendosal Indomethacin acemetacin cinmetacin sulindac tolmetin zomepirac diclofenac fenclofenac isoxepac furofenac fentiazac clidanac oxepinac…
Immunomodulation (reduced T cell activation) Inhibition of cyclooxygenase (COX) activity Production of novel anti-inflammatory lipid mediators, e.g. resolvins Direct fatty acid signaling via GPCRs Alteration of membrane dynamics and cell…
PubMed Avivi D, Moshkowitz M, Detering E, Arber N (2012) The role of low-dose aspirin in the prevention of colorectal cancer. Expert Opin Ther Targets PMID 22313430 1:s51−s62CrossRef Baron JA,…
Fig. 1 COX-2/mPGES-1 pathway. Two primary COX enzyme isoforms (COX-1 and COX-2) catalyze the rate-limiting step of PG formation: the conversion of AA into the intermediate metabolite PGG2, which is further…
Fig. 1 Relative risk of colorectal neoplasia in individuals using aspirin, NSAIDs and COX-2 inhibitors The COX enzyme is probably the most common therapeutic drug target in human history. Aspirin,…
