Fibrillary glomerulonephritis Overview and epidemiology Fibrillary glomerulonephritis (FGN) was first described in 1977. It is a rare disease, with incidence of less than 1% of native kidney biopsies. It is…
Introduction Systemic amyloidoses encompass a group of diseases characterized by deposition of abnormal, insoluble, misfolded, β-pleated protein fibrils in different organs. Amyloid protein positively stains with Congo red and demonstrates…
Introduction Sinusoidal obstruction syndrome (SOS) is a well-described complication of the high-dose conditioning regimens used in hematopoietic stem cell transplantation (HSCT), as well as certain hepatotoxic chemotherapies or radiation therapy…
Introduction Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the deposition of monoclonal light and/or heavy chains within glomerular, tubular, and vessel wall basement membranes. Three subtypes of MIDD have…
Key wordsKidney, hematopoietic cell transplant, graft-versus-host disease, transplant-associated thrombotic microangiopathy Kidney injury in graft versus host disease Introduction Hematopoietic cell transplant (HCT) is a commonly used procedure to treat…
Introduction Acute kidney injury (AKI) remains a common presentation of multiple myeloma (MM). Depending on the definition of AKI used, between 18% and 56% of patients with MM are affected….
Introduction This section of the book focuses on paraprotein-related kidney disorders. In this chapter, we describe a general overview of paraproteins and their adverse effects on the kidneys with emphasis…
Introduction Volume disorders are common in patients with cancer, given the vast array of organ dysfunction that occurs in these patients, as well as the frequent toxicities associated with many…
