© Springer International Publishing Switzerland 2015Vivian E. Strong (ed.)Gastric Cancer10.1007/978-3-319-15826-6_24 24. Targeted Therapy and Novel Agents for the Treatment of Gastric Cancer: A View Toward the Future Georgios D. Lianos1, Alberto Mangano2, Stefano Rausei3, Aikaterini Lianou4, Zoi Anastasiadi4, Gianlorenzo Dionigi5…
NAC Postop adjuvant Primary lesion Expecting shrinkage Resected Delayed resection Early resection Minimal spillage Spillage of tumor cells Micrometastasis Early treatment Delayed treatment Less influence by surgery Growth stimulation…
Fig. 23.1 Axial and coronal views of a radiotherapy plan showing the isodose lines to deliver the high dose to the postoperative bed and regional nodes and limiting the radiation…
Treatment No. of patients R0 resection rate (%) Pathologic CR rate Survival Local failure* Reference Median Overall Periop ECF + surgery 250 69 0 % 24 months 5-year 36 %…
Fig. 1.1 Theodor Billroth (1887) In the autumn of 2014, studying historical connections in the field of gastric cancer therapy led to a deepened understanding of therapeutic concepts comprising a…
Trial ID Title Primary sponsor Registration Web link NCT01065688 A trial of reconstruction after distal gastrectomy for gastric cancer Wakayama Medical University 08/02/2010 http://clinicaltrials.gov/show/NCT01065688 NCT01375738 Improving diabetes by reconstruction methods…
Fig. 18.1 Hereditary diffuse gastric cancer (HDGC) is associated with loss of E-cadherin gene expression. Immunohistochemistry of E-cadherin expression ( brown cells) in a patient with HDGC demonstrates that the…
Fig. 7.1 Age-standardized incidence ( blue + red columns) and mortality ( red columns) from gastric cancer in 2012 in men a and women b (GLOBOCAN 2012). Only countries with…
Exon Mutation Mutation type Ref. Exon Mutation Mutation type Ref. 1 Del exon 1–2 (19353 bp) Truncation [37] 10 1397-1398delTC Frameshift [24, 41] Del exon 1–2 (5761 bp) Truncation [37] 1466insC Frameshift…
Study Year published N Cyt+ (%) Factors associated with CYT+ Survival after resection Comments Bonenkamp [19] 1996 20 (4.4) T stage, presence of serosal invasion, nodal status CYT−: > 3 years…
