Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal Roles

Feb 5, 2019 by in NEPHROLOGY Comments Off on Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal Roles

Chapter Outline GENERAL INTRODUCTION TO ALDOSTERONE AND MINERALOCORTICOID RECEPTORS, 304 ALDOSTERONE SYNTHESIS, 305 MECHANISMS OF MINERALOCORTICOID RECEPTOR FUNCTION AND GENE REGULATION, 306 Mineralocorticoid Receptor Function as a Hormone-Regulated Transcription Factor:…

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Renal Acidification Mechanisms

Feb 5, 2019 by in NEPHROLOGY Comments Off on Renal Acidification Mechanisms

Chapter Outline BICARBONATE REABSORPTION, 234 Proximal Tubule, 234 Loop of Henle, 238 Distal Convoluted Tubule, 238 Collecting Duct, 239 BICARBONATE GENERATION, 246 Titratable Acid Excretion, 246 Organic Anion Excretion, 247…

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Vasoactive Molecules and the Kidney

Feb 5, 2019 by in NEPHROLOGY Comments Off on Vasoactive Molecules and the Kidney

Chapter Outline RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 325 Classical Renin-Angiotensin-Aldosterone System, 326 Expanded Renin-Angiotensin-Aldosterone System: Enzymes, Angiotensin Peptides, and Receptors, 331 Renin-Angiotensin-Aldosterone System in Kidney Pathophysiology, 334 ENDOTHELIN, 335 Structure, Synthesis, and Secretion…

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Metabolic Basis of Solute Transport

Feb 5, 2019 by in NEPHROLOGY Comments Off on Metabolic Basis of Solute Transport

Chapter Outline THERMODYNAMIC APPROACH TO METABOLISM AND TRANSPORT, 123 Thermodynamic Analysis of Kidney Function, 123 Application of the Laws of Thermodynamics to Kidney Function, 123 ENERGY AND THE SODIUM PUMP,…

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Embryology of the Kidney

Feb 5, 2019 by in NEPHROLOGY Comments Off on Embryology of the Kidney

Chapter Outline MAMMALIAN KIDNEY DEVELOPMENT: EMBRYOLOGY , 2 Development of the Urogenital System, 2 Development of the Metanephros, 3 Development of the Nephron, 4 The Nephrogenic Zone, 5 Branching Morphogenesis:…

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The Podocyte

Feb 5, 2019 by in NEPHROLOGY Comments Off on The Podocyte

Chapter Outline BIOLOGIC FUNCTIONS OF PODOCYTES, 112 ULTRASTRUCTURAL AND MOLECULAR ANATOMY OF PODOCYTES REQUIRED FOR NORMAL STRUCTURE AND FUNCTION, 113 Structure, 113 Slit Diaphragm Proteins, 113 Cytoskeleton, 113 GLOMERULAR DISEASES…

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