Radiation Treatment for Gastric Cancer
Fig. 23.1 Axial and coronal views of a radiotherapy plan showing the isodose lines to deliver the high dose to the postoperative bed and regional nodes and limiting the radiation…
GASTOINESTINAL SURGERY
Neoadjuvant and Adjuvant Treatment—Strategies and Clinical Trials—Western Perspective
Treatment No. of patients R0 resection rate (%) Pathologic CR rate Survival Local failure* Reference Median Overall Periop ECF + surgery 250 69 0 % 24 months 5-year 36 %…
The Historical Perspective of Gastric Cancer
Fig. 1.1 Theodor Billroth (1887) In the autumn of 2014, studying historical connections in the field of gastric cancer therapy led to a deepened understanding of therapeutic concepts comprising a…
Surgical Trials for Gastric Cancer
Trial ID Title Primary sponsor Registration Web link NCT01065688 A trial of reconstruction after distal gastrectomy for gastric cancer Wakayama Medical University 08/02/2010 http://clinicaltrials.gov/show/NCT01065688 NCT01375738 Improving diabetes by reconstruction methods…
Hereditary Diffuse Gastric Cancer
Fig. 18.1 Hereditary diffuse gastric cancer (HDGC) is associated with loss of E-cadherin gene expression. Immunohistochemistry of E-cadherin expression ( brown cells) in a patient with HDGC demonstrates that the…
Western Perspective and Epidemiology of Gastric Cancer
Fig. 7.1 Age-standardized incidence ( blue + red columns) and mortality ( red columns) from gastric cancer in 2012 in men a and women b (GLOBOCAN 2012). Only countries with…
Pathophysiology of Hereditary Diffuse Gastric Cancer
Exon Mutation Mutation type Ref. Exon Mutation Mutation type Ref. 1 Del exon 1–2 (19353 bp) Truncation [37] 10 1397-1398delTC Frameshift [24, 41] Del exon 1–2 (5761 bp) Truncation [37] 1466insC Frameshift…
The Role of Staging Laparoscopy and Peritoneal Cytology in Gastric Cancer
Study Year published N Cyt+ (%) Factors associated with CYT+ Survival after resection Comments Bonenkamp [19] 1996 20 (4.4) T stage, presence of serosal invasion, nodal status CYT−: > 3 years…
Lymphadenectomy—D1, D2, and D3
Fig. 13.1 Lymph node stations as described by the JRSGC Table 13.1 Lymph node stations and their anatomical borders [5] Station Description Anatomical border 1 Right cardiac Perigastric nodes on…
Epidemiology of Gastric Cancer
Fig. 2.1 Gastric cancer (GC) histotypes according to Laurèn classification. a. Intestinal-type GC: glandular cancer structures of different size infiltrating the gastric wall (H&E, original magnification 40 ×). b Diffuse-type GC:…
