Chapter 8 – Approach to the Infant with Cholestasis
Abstract Jaundice sometimes appears at birth, indicated by the dark yellow color of the countenance and arising from obstructions of the liver. Cases are generally incurable. Chapter 8 Approach to…
Chapter 6 – Portal Hypertension in Children
Abstract A portal system is one, which by definition, begins and ends with capillaries. The major portal system in humans is one in which the capillaries originate in the mesentery…
Chapter 5 – Cirrhosis and Chronic Liver Failure in Children
Abstract The word “cirrhosis” comes from the Greek kirrhos, meaning yellowish, tawny, and describes the gross pathology of the diseased liver. Since the late 1980s, however, clinicians have used the…
Chapter 7 – Laboratory Assessment of Liver Function and Injury in Children
Abstract The liver is a multifunctional organ that is involved in a number of critical excretory, synthetic and metabolic functions. Biochemical assessment of these functions in children is undertaken by…
Chapter 4 – Acute Liver Failure in Children
Abstract Pediatric acute liver failure (PALF) is not a single diagnosis. Rather, PALF is a complex, rapidly progressive clinical syndrome that is the final common pathway for many disparate conditions;…
Chapter 3 – Mechanisms of Bile Formation and the Pathogenesis of Cholestasis
Abstract Bile formation and flow is an essential physiological function. Adequate bile flow is necessary for innumerable daily functions including digestion, metabolism, growth, development, toxin elimination and adaptation to liver…
Chapter 2 – Functional Development of the Liver
Abstract The liver attains its highest relative size at about 10% of fetal weight at the ninth week of gestation. Early in gestation the liver is the primary site for…
Chapter 1 – Liver Development
Abstract The essential liver endocrine and exocrine functions require a precise spatial arrangement of the repeated hepatic lobule consisting of the central vein, portal vein, hepatic artery, intrahepatic bile duct…
Future of Liver Transplantation in Children
Introduction Liver transplantation was a dream only a century or so ago. The idea of replacing a diseased organ with a new one was a matter of science fiction. However,…
Challenges for Young People With Liver Disease Including Transition to Adult Services
Long-term outcomes following liver transplantation (LT) are inferior for adolescents and young adults in comparison with younger children and adults. Adolescence is a transitional stage of psychosocial development and a…
