Chapter 14 – Alagille Syndrome
Abstract Alagille syndrome (ALGS) is an autosomal dominant, multisystem disorder which was first described in 1969 by Daniel Alagille as a constellation of clinical features in five different organ systems…
Chapter 19 – Hepatitis C Virus Infection in Children
Abstract Hepatitis C virus (HCV) is an important cause of viral hepatitis in children and the actual number of infected children is clearly underestimated. HCV infection across the pediatric age…
Chapter 20 – Autoimmune Hepatitis in Children
Abstract Autoimmune hepatitis (AIH) is a progressive inflammatory disorder of unknown etiology, characterized histologically by interface hepatitis, serologically by the presence of non-organ specific autoantibodies, biochemically by elevated aminotransferases and…
Chapter 17 – Hepatitis A and Hepatitis E Virus in Children
Abstract Optimal care of children with viral hepatitis necessitates incorporation of recent advances in diagnosis, prevention, and treatment into clinical practice. Although primary viral infection of the liver has been…
Chapter 15 – Intestinal Failure Associated Liver Disease
Abstract Intestinal failure (IF) is defined as the end result of any gastrointestinal disorder in which functional intestinal mass is insufficient to allow adequate growth, hydration, and electrolyte balance in…
Chapter 12 – Neonatal Jaundice and Disorders of Bilirubin Metabolism
Abstract Elevation of the serum bilirubin level is a common finding during the first week of life. This can be a transient phenomenon that resolves spontaneously, or it can signify…
Chapter 13 – Familial Hepatocellular Cholestasis
Abstract Inherited cholestasis of hepatocellular origin has long been described in the neonate or during the first year of life [1]. Many of these infants were categorized as having idiopathic…
Chapter 11 – Biliary Atresia and Other Disorders of the Extrahepatic Bile Ducts
Abstract Biliary atresia and related disorders of the biliary tract, such as choledochal cysts, must be considered in the differential diagnosis of prolonged conjugated hyperbilirubinemia in the newborn (neonatal cholestasis)….
Chapter 10 – Neonatal Hepatitis and Congenital Infections
Abstract Neonatal hepatitis refers to a heterogeneous group of disorders that result in a somewhat similar morphologic change in the liver of an infant younger than three months of age…
Chapter 9 – Medical and Nutritional Management of Cholestasis in Infants and Children
Abstract When first encountering an infant or child with cholestatic liver disease, it is essential that diagnostic evaluation be conducted promptly in order to recognize disorders amenable either to specific…
