Chronic Graft Injury
Introduction Patient and graft survival after pediatric liver transplantation (LT) has improved significantly: children undergoing LT have a patient survival of 79% and graft survival of 63% 10 years post-transplant,…
Prospects for Immune Tolerance
Introduction The extraordinary success of liver transplantation (LT) as a treatment for end-stage liver diseases has resulted in the need to redirect research priorities and clinical resources toward improving the…
Psychosocial Outcomes After Pediatric Liver Transplantation
Introduction Liver transplantation (LT) is a lifesaving treatment for children with end-stage liver disease (ESLD). As immunosuppressive and surgical techniques have improved over time, long-term patient and graft survival rates…
Pediatric Liver Transplantation in Asia
Introduction The history of surgery begins with traditional medicine in India (Ayurveda since 2000 BCE) and China (Yin-Yang since 3000 BCE). Surgery began with the first attempt to control bleeding…
Pediatric Liver Transplantation in South America: Incidence and Indications
Introduction South America currently has approximately 430,485,637 inhabitants, 16.2% of whom are under the age of 18. Brazil is the most populous South American country (213,106,000 people), followed by Colombia…
Liver Retransplantation
Incidence and Indications—Early and Late Liver Retransplantation The incidence of graft failure after pediatric liver transplantation has been decreasing with surgical and medical progress, but still reaches 10% to 15%…
Metabolic Conditions
An inherited metabolic disorder is an increasingly common indication for liver transplantation (LT), accounting for more than 15% of pediatric cases worldwide and up to 30% in some specialist centers….
Liver Transplantation for Liver Tumors in Children
Introduction Primary liver tumors in the pediatric population are rare entities. Based on UK children’s cancer registry data (0–16 years old), in the period 2006 to 2008, a total of…
Auxiliary Liver Transplantation for Acute Liver Failure in Children
Introduction Acute liver failure (ALF) is defined as the acute onset of severe hepatitis with loss of hepatic function in patients with no known underlying liver disease. ALF can result…
Alagille Syndrome
Introduction Alagille syndrome (ALGS) is a rare multisystem disorder and one of the most frequent inherited causes of cholestatic liver disease in children. Traditionally, ALGS has been characterized by the…
