Histopathology of Liver LIVER MICROANATOMY AND INJURY PATTERNS Liver has three functional components: hepatocytes, central veins/sinusoids, portal tracts (triads) Basic architecture: cords of hepatocytes (one cell thick), separated by vascular…
Hepatorenal Syndrome (Am J Gastroenterol. 2005;100:460-67) DEFINITION: Renal failure (progressive azotemia) in patients with cirrhosis, liver failure, and portal hypertension EPIDEMIOLOGY: 10% of hospitalized patients with cirrhosis and ascites 20%…
Hepatocellular Carcinoma (Hepatology. 2005;42:1208-29) DEFINITION: Hepatocellular carcinoma (HCC) or Hepatoma is a primary (as opposed to metastases) tumor of the liver EPIDEMIOLOGY: Mortality: 4th most common cause of world cancer…
Hepatobiliary Cystic Disease BILE DUCT CYSTS: major classes and subtypes Ia: choledochal cyst Ib: segmental choledochal dilation Ic: diffuse or cylindrical duct dilation II: extrahepatic duct diverticula III: choledochocele IVa:…
Hepatitis C (Gastro 2006;130:225-30 & 231-64. Hepatology 2004;39:1147-71. Hepatology 2002;36:S3-20) DEFINITION: A hepatotrophic virus; the liver is the primary site of infection, replication and cellular damage Chronic hepatitis: presence of…
Hepatitis B (Hepatology 2007;45:507-39. Clin Gastroenterol Hepatol. 2006;4:936-62; Hepatology. 2004;39:1-5) DEFINITION: A hepatotrophic virus; the liver is the primary site of infection, replication and cellular damage Chronic hepatitis: presence of…
Hepatitis A, D, E HEPATITIS A Definition: A hepatotrophic virus; the liver is the primary site of infection, replication and cellular damage Epidemiology: Undeveloped countries: Africa, Asia, etc. In U.S.,…
Hemochromatosis & Iron Overload (Hepatology 2001;33:1321-28) DEFINITIONS: Hereditary Hemochromatosis (HH): Autosomal recessive inherited disorder of iron overload Increased iron absorption from the gut, with preferential deposition of iron in liver…
Drug & Toxic Induced Liver Disease DEFINITION: More than 600 medicines have been reported to cause liver injury; Two most common: Acetaminophen and Alcohol; See also Liver- Alcoholic Liver Disease…
Congenital Hepatic Fibrosis DEFINITION: Fibrous enlargement of the portal tracts with abnormally shaped bile ducts and no cirrhosis EPIDEMIOLOGY: Autosomal recessive; Most commonly presents in childhood, but can be diagnosed…
