Abstract Motility is the process of moving luminal contents through the gastrointestinal (GI) tract. However, motility encompasses many complex processes and is influenced by many internal and external factors. While…
Abstract The intestinal barrier is established by a single layer of polarized intestinal epithelial cells (IECs) separating bacteria in the intestinal lumen from the immune cells in the lamina propria….
Abstract The mammalian intestinal tract undergoes dramatic changes during the first few weeks of postnatal life. Genetic and neurohormonal regulators influence the changes in digestive and transport functions that mediate…
Abstract The cell cycle is a process in which a cell first duplicates its genetic information and then divides to give rise to two daughter cells. To avoid mis-segregation of…
Abstract The mechanisms that orchestrate the development of a multicellular organism from a single common ancestor cell have fascinated people for centuries. We are still a long way from truly…
Abstract The Notch signaling pathway is a key regulator of the intestinal epithelium, playing a fundamental role in stem cell maintenance, progenitor cell proliferation, and cell fate determination. Notch controls…
Abstract The intestine is the central tissue for digestion and absorption of nutrients. Moreover, the intestine provides tight functional barrier from the vast commensal bacteria that reside in the intestinal…
Abstract The intestine is a complex organ that has evolved to maximize the luminal surface area for the purpose of absorbing nutrients. The epithelial lining of the intestine must maintain…
Abstract Gastrointestinal (GI) tissues express a multitude of growth factors, broadly defined as naturally occurring polypeptides that elicit cellular growth, proliferation, or differentiation following binding to surface membrane receptors. In…
Abstract Gut peptides are key signaling molecules for the feedback control of gastrointestinal function and the coordination of central and peripheral responses to nutrient ingestion. Peptides are implicated in roles…
