Stem Cell Niche in the Kidney
Outline Introduction 233 Stem Cells in the Adult Kidney 233 Ontogenesis of the Renal Stem Cell Niche 235 The Adult Renal Stem Cell Niche 236 The Renal Niche in Aging…
Methods of Isolation and Culture of Adult Stem Cells
Outline Introduction 217 Methods for the Isolation and Culture of Bone Marrow Stem Cells 220 Isolation of the Bone Marrow or Cord Blood Mononuclear Fraction 220 Isolation and Cultivation of…
Potential of the Side Population in Regenerative Nephrology
Outline What is the Side Population? 173 Role of ABC Transporters: Markers or Mediators of Stem Cells 173 Existence of Side Population from Other Organs and their Association with Organ…
Very Small Embryonic-like Stem Cells and Their Potential Relevance for Kidney Homeostasis
Outline Introduction 189 Developmental Overview on Stem Cell Compartment 191 Deposition of Developmentally Early Stem Cells in Adult Tissues 191 Isolation of Very Small Embryonic-like Stem Cells 192 Regeneration Potential…
Use of Genetic Mouse Models to Study Kidney Regeneration
Outline Introduction 38 Genetic Modification In Vivo 38 Transgenic Expression 38 Manipulation of the Mouse Embryo 38 Pitfalls in Transgenic Mice and the Development of the Gene Trap ROSA26 Locus…
Glomerulogenesis and De Novo Nephrogenesis in Medaka Fish: An Evolutionary Approach
Outline Introduction 3 Medaka as a Model Animal for Kidney Research 4 General Advantages of Using Medaka 4 Notable Differences Between Humans (Mammals) and Medaka 4 An Example of Medaka…
Endothelial Progenitor Cells and the Kidney
Outline Introduction 167 The Concept of Endothelial Progenitor Cells 167 Endothelial Progenitor Cells as an Indicator of Cardiovascular Disease 168 Early Outgrowth Cells: Myeloid Endothelial Progenitor Cells 168 Circulating CD34…
Renal Organogenesis: Growing a Replacement Kidney In Situ from Transplanted Renal Primordia
Outline Introduction 19 Methodology for Organogenesis 20 Antigen Presentation 20 MHC Expression 21 Immune Response 21 Vascularization 22 Renal Organogenesis 23 Isotransplantation/Allotransplantation of Renal Primordia 23 Preservation Prior to Transplantation…
Endogenous Anti-inflammatory and Proresolving Lipid Mediators in Renal Disease
Outline Introduction 69 Lipid Mediators: Chemical Autacoids in Inflammation and Resolution 72 Lipoxins 72 Proresolving Pathways, Essential Fatty Acids and Resolution Indices 74 Aspirin is Resolution Friendly 74 Statins and…
Tissue Protection and Regeneration Aided by Erythropoietin and Erythropoietin-derived Peptides
Outline Introduction 93 Tissue Expression of Erythropoietin and the Erythropoietin Receptor 93 Erythropoietin in the Vascular System 94 Erythropoietin and the Endothelium 94 Erythropoietin and Endothelial Progenitor Cells 95 Erythropoietin…
