Principles of Radiotherapy in Urologic Tumors
The BED normally carries a subscript corresponding to the assumed α/β since it is clearly different for large and small α/β. Thus, for any given fractionation schedule, one must determine…
Genetics and Genito-Urinary Cancer
Fig. 3.1 Clonal evolution drives tumor progression. (a) Healthy epithelium. (b) The first oncogenic mutation occurs in a single epithelium cell (Yellow cell) resulting in the growth of a genetically…
Management of Metastatic Bladder Tumours
Regimens Reference N OR (%) CR (%) Survival (months) P MVAC [6] 120 36 13 12.5 <0.0002 Cisplatin 126 11 3 8.2 MVAC [7] 55 65 35 12.6 <0.05 CISCA…
Surgical Management of Bladder Cancer
1. Muscle invasive (≥T2) bladder cancer 2. Select patients with recurrent high grade T1 or CIS 3. BCG and intravesical chemotherapy failures: high grade T1, with concomitant CIS, multifocal disease…
Invasive Bladder Cancer: Combined Modality Treatment
Parameter Limitation Examples Laboratory methodology New assay system Standardization in progress What is “normal”? Optimal technology? e.g. I-H vs. FISH? e.g. RNA vs. protein? Inter-laboratory variation Lab test applied to…
Principles of Chemotherapy for Genitourinary Cancer
Fig. 13.1 Cell cycle (Reprinted from Kalmadi and Raghavan [43]. With permission from Springer Verlag) 1. Cells remain quiescent in a resting phase (G0), which may be prolonged over years;…
Life After Urological Cancer – Psychological Issues
Fig. 16.1 Comparison of emotional distress by cancer site Hinz and colleagues [11] looked at the degree of psychological distress (anxiety and depression) in urological cancer patients over a period…
Intravesical Therapy for Bladder Cancer
57. Herr HW, Dalbagni G. Defining bacillus Calmette-Guerin refractory superficial bladder tumors. J Urol. 2003;169(5):1706–8.PubMed 58. Solsona E, Iborra I, Dumont R, et al. The 3-month clinical response to intravesical…
Chemotherapy for Testicular Cancer
Variable 0 1 2 3 Primary site Gonadal Retroperitoneal Mediastinal Response 1st line CR/PRm- PRm+/SD PD PFI >3 months ≤3 months AFP at salvage normal <1,000 >1,000 LBB at salvage…
The Role of Radiotherapy in Testicular Cancer
© Springer-Verlag London 2015Vinod H. Nargund, Derek Raghavan and Howard M. Sandler (eds.)Urological Oncology10.1007/978-0-85729-482-1_30 30. The Role of Radiotherapy in Testicular Cancer Sophie D. Fossa1 and Jan Oldenburg2 (1) Department of Oncology, Oslo University Hospital, Montebello, Oslo, Norway (2)…
