Diagnostic Considerations and Clinical End Points for Nonalcoholic Steatohepatitis
End points related to how a patient feels – Quality of life End points related to how a patient functions – Days from work lost – Ability to carry on…
Hepatic and Extrahepatic Malignancies in NAFLD
Author, year [ref.] Country/setting/period Study design/cohort definition/control group Number of patients/follow-up HCC incidence in cohort vs. control group HCC mortality in cohort vs. control group Sorensen et al., 1998 [57]…
Global Epidemiology and Risk Factors for Nonalcoholic Fatty Liver Disease
Author, year Country Population Sample size (n) Prevalence of NAFLD (%) Mode of diagnosis Ref. No. Price, 2014 USA HIV+ and HIV− men in the Multicenter AIDS Cohort Study. N = 719…
Animal Models of Nonalcoholic Fatty Liver Disease
Model Description Advantages Limitations Methionine-choline-deficient diet (MCD) •High-sucrose (40 %) and high-fat (10–20 %) diet lacking methionine and choline •Impaired VLDL assembly and β-oxidation of fatty acids •Day 10: NASH…
Nonalcoholic Fatty Liver Disease in Children
Author Comparators N Population Findings ALT Larrieta-Carrasco et al. [58] ALT ≤ or >35 U/L 1037 Overweight Mexican children aged 6–12 PNPLA3 GG genotype had 3.7 times the odds for…
Small Bowel Transplantation
Fig. 29.1 An isolated apoptotic body in a crypt. Less than six apoptotic bodies per ten crypt cross sections are seen in cases graded as indeterminate for acute rejection (H&E…
Abdominal Wall Transplantation and Technique
Fig. 26.1 Patient candidate for abdominal wall transplantation. The wall is severely damaged from repeated laparotomies and enterocutaneous fistulae Fig. 26.2 At the end of bowel transplantation, the recipient abdominal…
Intestinal/Multivisceral Transplantation
Fig. 25.1 Graft types: (a) isolated intestinal graft; (b) combined liver-intestinal graft; (c) multivisceral graft 25.3 Graft Types and Indications The use of the three main types of intestinal graft…
