The Historical Perspective of Gastric Cancer
Fig. 1.1 Theodor Billroth (1887) In the autumn of 2014, studying historical connections in the field of gastric cancer therapy led to a deepened understanding of therapeutic concepts comprising a…
Neoadjuvant and Adjuvant Treatment—Strategies and Clinical Trials—Western Perspective
Treatment No. of patients R0 resection rate (%) Pathologic CR rate Survival Local failure* Reference Median Overall Periop ECF + surgery 250 69 0 % 24 months 5-year 36 %…
Surgical Trials for Gastric Cancer
Trial ID Title Primary sponsor Registration Web link NCT01065688 A trial of reconstruction after distal gastrectomy for gastric cancer Wakayama Medical University 08/02/2010 http://clinicaltrials.gov/show/NCT01065688 NCT01375738 Improving diabetes by reconstruction methods…
Hereditary Diffuse Gastric Cancer
Fig. 18.1 Hereditary diffuse gastric cancer (HDGC) is associated with loss of E-cadherin gene expression. Immunohistochemistry of E-cadherin expression ( brown cells) in a patient with HDGC demonstrates that the…
Western Perspective and Epidemiology of Gastric Cancer
Fig. 7.1 Age-standardized incidence ( blue + red columns) and mortality ( red columns) from gastric cancer in 2012 in men a and women b (GLOBOCAN 2012). Only countries with…
Pathophysiology of Hereditary Diffuse Gastric Cancer
Exon Mutation Mutation type Ref. Exon Mutation Mutation type Ref. 1 Del exon 1–2 (19353 bp) Truncation [37] 10 1397-1398delTC Frameshift [24, 41] Del exon 1–2 (5761 bp) Truncation [37] 1466insC Frameshift…
The Role of Staging Laparoscopy and Peritoneal Cytology in Gastric Cancer
Study Year published N Cyt+ (%) Factors associated with CYT+ Survival after resection Comments Bonenkamp [19] 1996 20 (4.4) T stage, presence of serosal invasion, nodal status CYT−: > 3 years…
Lymphadenectomy—D1, D2, and D3
Fig. 13.1 Lymph node stations as described by the JRSGC Table 13.1 Lymph node stations and their anatomical borders [5] Station Description Anatomical border 1 Right cardiac Perigastric nodes on…
Epidemiology of Gastric Cancer
Fig. 2.1 Gastric cancer (GC) histotypes according to Laurèn classification. a. Intestinal-type GC: glandular cancer structures of different size infiltrating the gastric wall (H&E, original magnification 40 ×). b Diffuse-type GC:…
Role of HER2 in Gastric Cancers
Fig. 5.1 Specificity of 89Zr-trastuzumab for HER2-positive tumors. Coronal 89Zr-trastuzumab, 18F-FDG, and 18F-FLT PET images of athymic nude mice bearing subcutaneous HER2-positive NCI-N87 ( left) and HER2-negative MKN-74 ( right)…
