Stem Cell Banking
Outline Introduction 409 Basic Principles of Cell Banking 410 Donation 410 Collection 411 Processing 411 Cell Suspension 412 Cell Selection 413 Cryopreservation 415 Storage 417 Selection of Cells for Transplantation…
Treatment of Acute Kidney Injury with Allogeneic Mesenchymal Stem Cells: Preclinical and Initial Clinical Data
Outline Acute Kidney Injury: Clinical and Experimental Issues 316 Clinical Acute Kidney Injury 316 Treatment Resistance of Clinical Acute Kidney Injury 317 Experimental Models of Acute Kidney Injury 317 Design…
Tissue Engineering in Urology
Outline Introduction 389 Basic Components of Tissue Engineering 390 Cells 390 Native Cells 390 Embryonic Stem Cells 390 Therapeutic Cloning (Somatic Cell Nuclear Transfer) 391 Reprogrammed Somatic Cells 391 Placental…
Potential Risks of Stem Cell Therapies
Outline Introduction 361 Characteristics of Mesenchymal Stem Cells 362 Characteristics of Induced Pluripotent Stem Cells 363 Technical Caveats in Stem Cell Preparation and Administration 364 Standardization of Stem Cell Methodology…
Ethics in Regenerative Medicine
Outline Introduction 401 Alternative Methods 403 Adult Stem Cells 403 Multipotent Stem Cells from Extraembryonic Tissues 404 Umbilical Cord as Stem Cell Source 404 Placenta, Amnion and Amniotic Fluid as…
Clinical Trials in Renal Regenerative Medicine
Outline Introduction 341 Clinical Trials of Regenerative Medicine in Other Disciplines 342 Therapeutic Neovascularization in Cardiovascular Medicine 342 Hepatic Regeneration 345 Clinical Trials on Renal Regeneration 346 Future Perspectives in…
Imaging of Transplanted and Native Stem Cells
Outline Introduction 257 Methodologies for Labeling Stem Cells 258 Imaging Modalities 258 Histology 258 Direct Labeling 258 Indirect Labeling 258 Optical Imaging 260 Direct Labeling 260 Indirect Labeling 260 Application…
Stem Cell Injury and Premature Senescence
Outline Introduction 275 Molecular Mechanisms of Stem Cell Exhaustion 277 Reactive Oxygen Species 277 Proinflammatory Cytokines 277 Proatherogenic Risk Factors 278 mTOR–Wnt Pathway 278 Adrenergic and GABA Receptor Stimulation 278…
Bone Marrow Mesenchymal Stem Cells in Organ Repair and Strategies to Optimize their Efficacy
Outline Introduction 299 Do Adult Bone Marrow-derived Stem Cells Participate in Kidney Repair? 300 Bone Marrow Mesenchymal Stem Cell Therapy Contributes to Renal Repair 300 Mesenchymal Stem Cells 300 Functional…
Regeneration and Aging: Regulation by Sirtuins and the NAD +Salvage Pathway
Outline Introduction 289 Aging of the Kidney 289 Aging of Parenchymal and Stromal Compartments 290 Aging of the Renal Vasculature 290 Cellular Basis of Tissue Aging 291 Cellular Senescence 291…
