Systemic Mastocytosis Systemic mastocytosis is characterized by mast cell proliferation in skin, bones, lymph nodes, and parenchymal organs. Patients usually present with classic dermatologic findings of urticaria pigmentosa. Typical symptoms…
Nutritional Disorders Severe nutritional deficiency can produce marked small intestinal abnormalities. The classic example is kwashiorkor. Malnutrition of this severity seldom occurs in developed countries, but less severe forms may…
Eosinophilic Diseases Food Allergies Up to 45% of the population report adverse reactions to food (572). Various enteric antigens play a role in the pathogenesis of conditions loosely termed food…
Granulomatous and Histiocytic Inflammatory Conditions Small intestinal granulomas form in many disorders (Table 6.15). The nature of the granulomas varies significantly from small macrophage collections that may or may not…
Interpretation of Ileal Biopsies Ileal biopsies are commonly taken when patients undergo colonoscopy. As a result, pathologists often have the opportunity to examine changes that may be present in the…
The Neoplastic Stomach Gastric neoplasms constitute a heterogeneous group of tumors; most are adenocarcinomas. Less common gastric cancers, such as lymphomas, neuroendocrine tumors, and stromal tumors, are discussed in Chapters…
Lipid Malabsorption The three major forms of lipid malabsorption are abetalipoproteinemia, familial hypobetalipoproteinemia (565), and diabetes. Several other related syndromes result in lipid accumulations in enterocytes producing histologic patterns indistinguishable…
Celiac Disease Celiac disease (CD), also known as gluten-sensitive enteropathy and celiac sprue, is a malabsorptive disease in which the intestinal mucosa is injured as a result of ingestion of…
Malabsorptive Diarrhea Malabsorptive diarrhea is a newly discovered autosomal recessive disorder that presents as congenital malabsorptive diarrhea and an almost complete absence of intestinal endocrine cells. The patients present in…
Autoimmune Enteropathy Autoimmune enteropathy is a life-threatening disorder of infancy that almost exclusively affects males. It is characterized by intractable diarrhea and a constellation of associated autoimmune diseases, including membranous…
