HEPATOPANCREATOBILIARY

Alagille Syndrome

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Alagille Syndrome

Introduction Alagille syndrome (ALGS) is a rare multisystem disorder and one of the most frequent inherited causes of cholestatic liver disease in children. Traditionally, ALGS has been characterized by the…

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Gene Therapy

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Gene Therapy

Introduction In recent years, the number of gene therapy (GT) trials targeting the liver have grown significantly, particularly when it comes to gene addition strategies (delivery of cDNA for a…

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Biliary Atresia

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Biliary Atresia

Introduction Biliary atresia is a uniquely perinatal disease that 30 years ago would have been universally fatal. With the development of the palliative Kasai portoenterostomy (Morio Kasai, 1922–2008), along with…

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Cell Transplantation

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Cell Transplantation

Introduction For numerous liver diseases of childhood, liver transplantation (LT) is a lifesaving procedure. However, it requires scarce organs, a highly experienced team to manage the surgical procedure, complications, and…

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Liver Assist Systems in Pediatric Liver Failure

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Liver Assist Systems in Pediatric Liver Failure

Introduction Currently, the standard medical treatment (SMT) for pediatric liver failure incorporates optimal supportive care with hemodynamic and respiratory support, infection control, and avoidance of gastrointestinal bleeding, aiming to bridge…

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Anti-infection Strategies

Feb 23, 2021 by in HEPATOPANCREATOBILIARY Comments Off on Anti-infection Strategies

Anti-infection Strategies Infections are the cause of significant morbidity and mortality after transplantation, both in the immediate post-operative period and beyond ( Fig. 19.1 ). Anti-infection strategies include preventive measures,…

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