Interpretation of Ileal Biopsies
Interpretation of Ileal Biopsies Ileal biopsies are commonly taken when patients undergo colonoscopy. As a result, pathologists often have the opportunity to examine changes that may be present in the…
GASTROENTEROLOGY
The Neoplastic Stomach
The Neoplastic Stomach Gastric neoplasms constitute a heterogeneous group of tumors; most are adenocarcinomas. Less common gastric cancers, such as lymphomas, neuroendocrine tumors, and stromal tumors, are discussed in Chapters…
Lipid Malabsorption
Lipid Malabsorption The three major forms of lipid malabsorption are abetalipoproteinemia, familial hypobetalipoproteinemia (565), and diabetes. Several other related syndromes result in lipid accumulations in enterocytes producing histologic patterns indistinguishable…
Celiac Disease
Celiac Disease Celiac disease (CD), also known as gluten-sensitive enteropathy and celiac sprue, is a malabsorptive disease in which the intestinal mucosa is injured as a result of ingestion of…
Malabsorptive Diarrhea
Malabsorptive Diarrhea Malabsorptive diarrhea is a newly discovered autosomal recessive disorder that presents as congenital malabsorptive diarrhea and an almost complete absence of intestinal endocrine cells. The patients present in…
Autoimmune Enteropathy
Autoimmune Enteropathy Autoimmune enteropathy is a life-threatening disorder of infancy that almost exclusively affects males. It is characterized by intractable diarrhea and a constellation of associated autoimmune diseases, including membranous…
Microvillous Inclusion Disease
Microvillous Inclusion Disease Microvillous inclusion disease (MID) occurs worldwide in infants from varying ethnic backgrounds. The disease may have a familial component as it sometimes occurs in multiple siblings (543)….
Intestinal Goblet Cell Autoantibody-Associated Enteropathy
Intestinal Goblet Cell Autoantibody-Associated Enteropathy There is a second form of autoimmune enteropathy that is characterized by the presence of circulating antibodies to goblet cells. These can be demonstrated using…
Malabsorption Syndromes
Malabsorption Syndromes Malabsorption results from premucosal, mucosal, and postmucosal diseases (Table 6.26). In premucosal diseases, defective digestion and absorption results from pancreatic or other systemic diseases and reduced bile salt…
Congenital Abnormalities
Congenital Abnormalities Intestinal Malpositions Intestinal malpositions include disorders of malrotation, malfixation, reversed rotation, incomplete rotations, fixation abnormalities, and situs inversus. Intestinal malrotations or nonrotations (Fig. 6.44) result from disordered or…
