Disease Reference Nonalcoholic steatohepatitis [21] Hepatitis [22, 23] Fulminant hepatitis [11, 24] Liver injury [11, 25] Liver fibrosis [11] Rejection after the transplantation [26] Obesity [11, 27, 28] Diabetes [11,…
Fig. 3.1 Proposed mechanism of liver regeneration by bone marrow cell (BMC) infusion Fig. 3.2 Overview of “study on the efficacy and safety of autologous bone marrow cell infusion therapy…
Study Treatment arm Control arm Number of patients Outcomes Treatment arm vs control arm (%) p-value Takayama et al. [9] CIK Radical resection 150 5-year DFS 38 vs 22 p < 0.05 …
© Springer Japan 2016Shuji Terai and Takeshi Suda (eds.)Gene Therapy and Cell Therapy Through the Liver10.1007/978-4-431-55666-4_10 10. Regulation for Gene and Cell Therapy Medicinal Products in Europe Matthias Renner1 , Brigitte Anliker1, Egbert Flory1, Jürgen Scherer1, Martina Schüßler-Lenz1, Matthias Schweizer1 and Zoltán Ivics1…
Fig. 12.1 Risk categories of first–third-class regenerative medicine technologies To implement a plan for the provision of first-class regenerative medicine, the provider is required to submit a plan to the…
© Springer Japan 2016Shuji Terai and Takeshi Suda (eds.)Gene Therapy and Cell Therapy Through the Liver10.1007/978-4-431-55666-4_1 1. Liver-Targeted Gene and Cell Therapies: An Overview Mohammad Alsaggar1 and Dexi Liu1 (1) Department of Pharmaceutical and Biomedical Sciences, University…
8. Kobayashi Y, Okada Y, Itakura G, Iwai H, Nishimura S, Yasuda A, et al. Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in…
Fig. 2.1 Macrophage has multiple critical roles during differentiation of HPC to hepatocytes. During liver damage TWEAK expressing macrophage stimulates HPC expansion. Hepatocyte debris eating macrophage determine the fate of…
Medical factors Failure of medical therapy Probability of survival without transplant MELD score Pulmonary status Renal failure Infection Surgical factors Probability of survival with transplant Age BMI Technical complexity (anatomic…
Fig. 5.1 Absolute number of liver transplants for patients with PBC by year [6] 5.3 Survival Following Liver Transplantation for PBC Patient and graft survival for PBC are excellent compared…
