Dedication
Philip G. McManis, MD I would like to dedicate this issue of the Gastroenterology Clinics of North America to a colleague, Associate Professor Philip G. McManis, MD, who died peacefully…
GASTROENTEROLOGY
Balancing Risks and Benefits of Cyclooxygenase-2 Selective Nonsteroidal Anti-Inflammatory Drugs
The recognition that nonsteroidal anti-inflammatory drugs (NSAIDs) increase not only gastrointestinal (GI) but cardiovascular (CV) adverse events as well has created a dilemma for practicing physicians. Clinicians selecting appropriate NSAID…
Differences in Peptic Ulcer Between the East and the West
Despite improved understanding of peptic ulcer disease (PUD) pathogenesis, advances in diagnostic modalities, and the availability of modern pharmalogical, endoscopic and surgical treatments, gastroduodenal ulcer remains a major cause of…
Helicobacter pylori -Negative Nonsteroidal Anti-Inflammatory Drug-Negative Ulcer
A vast majority of ulcers of the stomach and duodenum are due to H pylori infection or nonsteroidal anti-inflammatory drug (NSAID) usage. In patients with apparent H pylori negative NSAID…
Nonsteroidal Anti-Inflammatory Drugs and Lower Gastrointestinal Complications
Nonsteroidal anti-inflammatory drug (NSAID)-associated intestinal damage to the small and/or large bowel is frequent and may be present in up to 60% to 70% of patients taking these drugs long…
Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulcer: Looking to the Future
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for treatment of pain and inflammation, despite their association with gastrointestinal complications, including bleeding and perforation. Inhibition of cyclooxygenases (COXs), is the main…
Management of Patients with High Gastrointestinal Risk on Antiplatelet Therapy
Increasing use of antiplatelet therapies is associated with increasing GI complications, such as ulceration and GI bleeding. Identification of high-risk patients and, in such patients, incorporation of strategies to reduce…
Refractory Peptic Ulcer Disease
Refractory peptic ulcer disease (PUD) manifests as either hemorrhagic complications (persistent or recurrent bleeding) or gastrointestinal (GI) complications (perforation, stricture, obstruction). Treatment strategies for hemorrhagic complications include Endoscopic therapy, surgery,…
Stress-Induced Ulcer Bleed ing in Critically Ill Patients
Stress-ulcer bleeding in critically ill patients develops as a result of various risk factors, notably prolonged mechanical ventilation and coagulopathy. The incidence of clinically significant bleeding is decreasing secondary to…
Predicting Poor Outcome from Acute Upper Gastrointestinal Hemorrhage
Acute upper gastrointestinal (GI) hemorrhage is one of the commonest causes for hospitalization worldwide. Endoscopic therapy is effective in achieving primary hemostasis. The shift of management from the operating theater…
