Glomerular Disease of Complement Dysregulation (C3 Glomerulopathy, Atypical Hemolytic-Uremic Syndrome) Mathieu Lemaire Bradley P. Dixon INTRODUCTION/GENERAL CONSIDERATIONS Dysregulation of the complement alternative pathway (CAP) plays a key role in the…
Glomerular Diseases Associated With Cancer and Its Treatment Purva Sharma Kenar D. Jhaveri Jaya Kala INTRODUCTION Onconephrology is a new subspecialty of nephrology that recognizes the important intersections of kidney…
Peri-infectious Glomerulonephritis Associated With Viral Infections Qiyu Wang Meghan Sise INTRODUCTION Chronic viral infections, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) can cause…
Bacterial Infection-Associated Glomerulonephritis in Adults and Children Kikachukwu Otiono Rahul Chanchlani INTRODUCTION AND GENERAL CONSIDERATIONS Infection-associated glomerulonephritis (IAGN) describes a spectrum of glomerular diseases associated with bacterial, viral, fungal, and…
Drug-Related Glomerulonephritis Frank Cortazar DRUG-INDUCED GLOMERULAR DISEASE Drugs are an important yet underrecognized cause of glomerular disease. The mechanisms of drug-induced glomerular disease are diverse, ranging from direct podocyte toxicity…
Non-amyloid Monoclonal Immunoglobulin-Related Diseases Virginie Royal Sabine Karam Nelson Leung INTRODUCTION Monoclonal gammopathy refers to the presence of a monoclonal protein detected in the plasma and/or urine, which is produced…
Amyloidosis Patrick Taus Virginie Royal Koyal Jain INTRODUCTION Amyloidosis is a group of rare diseases caused by extracellular deposition of insoluble misfolded fibrillary protein aggregates termed amyloid. It occurs in…
Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis and Anti-Glomerular Basement Membrane (Anti-GBM) Disease Katti Woerner Jason Kidd ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY-ASSOCIATED VASCULITIS Introduction/General Considerations Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a necrotizing…
Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis Manish K. Saha Mahmoud Kallash IMMUNOGLOBULIN A NEPHROPATHY IN ADULTS Epidemiology Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis (GN) in the…
Lupus Nephritis (Including Antiphospholipid Antibody Syndrome) Dawn J. Caster Scott E. Wenderfer INTRODUCTION AND GENERAL CONSIDERATIONS Lupus nephritis (LN) is a common cause of glomerular disease. The prevalence of systemic…
