Abstract The recognition of specific oesophageal infections and the distinction between gastro-oesophageal reflux disease and rarer forms of oesophagitis are key tasks for gastrointestinal pathologists reading mucosal biopsies. Infections can…
Abstract A common clinical indication for duodenal biopsy is the exclusion of coeliac disease / gluten sensitive enteropathy. However, a variety of inflammatory and infectious disorders may affect the duodenum,…
Abstract Biopsies of gastric mucosa, obtained at endoscopy, are common in routine pathology practice. The material ranges from single random biopsies of macroscopically normal or near-normal mucosa to detailed series…
Abstract Therapeutic radiation for cancer is more than 100 years old. Side effects constitute the main limitation to its use. Side effects may be acute or chronic, but these categories…
Abstract The term “dysplasia” refers to “an unequivocal neoplastic epithelial alteration without invasive growth”. The term “intraepithelial neoplasia” often replaces “dysplasia” in World Health Organisation (WHO) guidance. Dysplasia is a…
Abstract Gastro-oesophageal reflux disease (GORD) is a condition that develops as a result of retrograde flow (reflux) of gastro-duodenal contents into the oesophagus, with or without mucosal tissue damage. The…
Abstract There are significant differences between paediatric and adult gastrointestinal (GI) disease, and even the normal GI histology shows some variation. Excess eosinophils in the gut can be present in…
Abstract An ever increasing number of drugs are known to cause gastrointestinal injury. The histological features are often non-specific and a single drug can induce many different patterns, necessitating close…
Abstract The assessment of gastrointestinal specimens from immunosuppressed patients can be challenging, particularly because of the increased likelihood of multiple diseases and of rarer diseases. This chapter documents and presents…
Abstract This chapter serves as a guide to gastrointestinal (GI) endoscopy for the histopathologist for benign pathology and outlines the value to endoscopists of GI biopsies. It sets out to…
