Abstract The liver is a multifunctional organ that is involved in a number of critical excretory, synthetic and metabolic functions. Biochemical assessment of these functions in children is undertaken by…
Abstract Pediatric acute liver failure (PALF) is not a single diagnosis. Rather, PALF is a complex, rapidly progressive clinical syndrome that is the final common pathway for many disparate conditions;…
Abstract Bile formation and flow is an essential physiological function. Adequate bile flow is necessary for innumerable daily functions including digestion, metabolism, growth, development, toxin elimination and adaptation to liver…
Abstract The liver attains its highest relative size at about 10% of fetal weight at the ninth week of gestation. Early in gestation the liver is the primary site for…
Abstract The essential liver endocrine and exocrine functions require a precise spatial arrangement of the repeated hepatic lobule consisting of the central vein, portal vein, hepatic artery, intrahepatic bile duct…
Introduction Liver transplantation was a dream only a century or so ago. The idea of replacing a diseased organ with a new one was a matter of science fiction. However,…
Long-term outcomes following liver transplantation (LT) are inferior for adolescents and young adults in comparison with younger children and adults. Adolescence is a transitional stage of psychosocial development and a…
Introduction Patient and graft survival after pediatric liver transplantation (LT) has improved significantly: children undergoing LT have a patient survival of 79% and graft survival of 63% 10 years post-transplant,…
Introduction The extraordinary success of liver transplantation (LT) as a treatment for end-stage liver diseases has resulted in the need to redirect research priorities and clinical resources toward improving the…
Introduction Liver transplantation (LT) is a lifesaving treatment for children with end-stage liver disease (ESLD). As immunosuppressive and surgical techniques have improved over time, long-term patient and graft survival rates…
