Drug-Related Glomerulonephritis Frank Cortazar DRUG-INDUCED GLOMERULAR DISEASE Drugs are an important yet underrecognized cause of glomerular disease. The mechanisms of drug-induced glomerular disease are diverse, ranging from direct podocyte toxicity…
Non-amyloid Monoclonal Immunoglobulin-Related Diseases Virginie Royal Sabine Karam Nelson Leung INTRODUCTION Monoclonal gammopathy refers to the presence of a monoclonal protein detected in the plasma and/or urine, which is produced…
Amyloidosis Patrick Taus Virginie Royal Koyal Jain INTRODUCTION Amyloidosis is a group of rare diseases caused by extracellular deposition of insoluble misfolded fibrillary protein aggregates termed amyloid. It occurs in…
Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis and Anti-Glomerular Basement Membrane (Anti-GBM) Disease Katti Woerner Jason Kidd ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY-ASSOCIATED VASCULITIS Introduction/General Considerations Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a necrotizing…
Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis Manish K. Saha Mahmoud Kallash IMMUNOGLOBULIN A NEPHROPATHY IN ADULTS Epidemiology Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis (GN) in the…
Lupus Nephritis (Including Antiphospholipid Antibody Syndrome) Dawn J. Caster Scott E. Wenderfer INTRODUCTION AND GENERAL CONSIDERATIONS Lupus nephritis (LN) is a common cause of glomerular disease. The prevalence of systemic…
Diabetic Kidney Disease Radica Z. Alicic Joshua J. Neumiller Katherine R. Tuttle INTRODUCTION Diabetes mellitus (DM), owing in part to the classic presenting symptom of polyuria, has long been associated…
Fibrillary and Immunotactoid Glomerulonephritis Rupali S. Avasare Samar M. Said Samih H. Nasr FIBRILLARY GLOMERULONEPHRITIS Introduction/General Considerations Fibrillary glomerulonephritis (FGN) is a rare glomerular disease first described by Rosenmann and…
Membranous Nephropathy Anne M. Kouri Sonia Boyer-Sauvet Michelle M. O’Shaughnessy INTRODUCTION/GENERAL CONSIDERATIONS Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults without diabetes, and the estimated incidence…
Congenital Nephrotic Syndrome Shanthi S. Balani Sarah J. Kizilbash INTRODUCTION Nephrotic syndrome is a heterogeneous group of disorders classically characterized by a triad of massive proteinuria, hypoalbuminemia, and edema. Based…
