Fig. 1.1 Flow-chart summary of literature search and study selection We found 22 RCTs to date (11 June 2014) on ADPKD management (Table 1.1). Most (16 of 22) of the…
Parameters Yes No Comment Validity Is the Randomization Procedure well described? +1 A computer-generated randomization method was used. Baseline variables were well balanced without any significant difference Double blinded? +2 …
A subset of focal nodular hyperplasias can have ballooning and Mallory hyaline (eFig. 20.3). Fatty change is less common, but when fat is present along with the balloon cells and…
Chronic biliary obstructive disease is most commonly encountered with primary sclerosing cholangitis, chronic pancreatic disease with duct stricturing, or anastomotic strictures after liver transplantation, but other less common causes of…
Differential The main histologic finding in clinically acute biliary obstruction is a bile ductular reaction, which may be accompanied by lobular cholestasis but has minimal lobular inflammatory changes. However, a…
Minimal to mild nonspecific chronic portal inflammation is common in potential donor liver biopsies, but if the portal inflammation is diffuse or more than mild, the donor may have an…
The inflammatory grade is typically determined by adding up the individual scores for inflammation in the portal tracts, interface activity, and lobular inflammation to reach a composite inflammatory grade, although…
In most cases, the hepatitic injury will resolve after stopping the drug, but it may take months for the liver enzymes to completely normalize. In general, cases with significant cholestasis…
Differential The most common mimic of the globules of α1-antitrypsin deficiency is megamitochondria. The location can often be a helpful clue because megamitochondria tend to be randomly distributed, whereas the…
The amount of fat is generally scored as minimal (less than 5%), mild (6% to 33%), moderate (34% to 66%), or marked (more than 67%). The general consensus is that…
