© Springer-Verlag London 2015Vinod H. Nargund, Derek Raghavan and Howard M. Sandler (eds.)Urological Oncology10.1007/978-0-85729-482-1_47 47. Management of Locally Advanced Prostate Cancer Elaine T. Lam1 and L. Michael Glodé1 (1) Division of Medical Oncology, Department of Medicine, University of Colorado, Aurora,…
1. Patients with previous abdominal/pelvic surgery 2. High body mass index 3. Previous prostatic surgery 4. Kidney transplantation/mesh abdominal repair The proponents of RPP describe it as procedure that provides…
Risk group Combination of pretreatment variables Low ≤T2a and PSA ≤10 ng/ml and GS ≤6 Intermediate T2b or PSA 10.1–20 ng/ml or GS = 7 High ≥T2c or PSA >20 ng/ml or…
© Springer-Verlag London 2015Vinod H. Nargund, Derek Raghavan and Howard M. Sandler (eds.)Urological Oncology10.1007/978-0-85729-482-1_41 41. Expectant Management of Localized Prostate Cancer Maria Carmen Mir1 and Andrew J. Stephenson2 (1) Department of Urology, Cleveland Clinic, Cleveland, OH, USA (2) Glickman Urological…
The BED normally carries a subscript corresponding to the assumed α/β since it is clearly different for large and small α/β. Thus, for any given fractionation schedule, one must determine…
Fig. 3.1 Clonal evolution drives tumor progression. (a) Healthy epithelium. (b) The first oncogenic mutation occurs in a single epithelium cell (Yellow cell) resulting in the growth of a genetically…
Regimens Reference N OR (%) CR (%) Survival (months) P MVAC [6] 120 36 13 12.5 <0.0002 Cisplatin 126 11 3 8.2 MVAC [7] 55 65 35 12.6 <0.05 CISCA…
1. Muscle invasive (≥T2) bladder cancer 2. Select patients with recurrent high grade T1 or CIS 3. BCG and intravesical chemotherapy failures: high grade T1, with concomitant CIS, multifocal disease…
Parameter Limitation Examples Laboratory methodology New assay system Standardization in progress What is “normal”? Optimal technology? e.g. I-H vs. FISH? e.g. RNA vs. protein? Inter-laboratory variation Lab test applied to…
Fig. 13.1 Cell cycle (Reprinted from Kalmadi and Raghavan [43]. With permission from Springer Verlag) 1. Cells remain quiescent in a resting phase (G0), which may be prolonged over years;…
