Cell-Based Immunotherapy for HCC: Our Experiences and Future Directions
Study Treatment arm Control arm Number of patients Outcomes Treatment arm vs control arm (%) p-value Takayama et al. [9] CIK Radical resection 150 5-year DFS 38 vs 22 p < 0.05 …
Regulation for Gene and Cell Therapy Medicinal Products in Europe
© Springer Japan 2016Shuji Terai and Takeshi Suda (eds.)Gene Therapy and Cell Therapy Through the Liver10.1007/978-4-431-55666-4_10 10. Regulation for Gene and Cell Therapy Medicinal Products in Europe Matthias Renner1 , Brigitte Anliker1, Egbert Flory1, Jürgen Scherer1, Martina Schüßler-Lenz1, Matthias Schweizer1 and Zoltán Ivics1…
The Way to Clinical Application of Human Pluripotent Stem Cells
8. Kobayashi Y, Okada Y, Itakura G, Iwai H, Nishimura S, Yasuda A, et al. Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in…
Macrophage Therapy for Liver Fibrosis and Regeneration
Fig. 2.1 Macrophage has multiple critical roles during differentiation of HPC to hepatocytes. During liver damage TWEAK expressing macrophage stimulates HPC expansion. Hepatocyte debris eating macrophage determine the fate of…
Liver-Targeted Gene and Cell Therapies: An Overview
© Springer Japan 2016Shuji Terai and Takeshi Suda (eds.)Gene Therapy and Cell Therapy Through the Liver10.1007/978-4-431-55666-4_1 1. Liver-Targeted Gene and Cell Therapies: An Overview Mohammad Alsaggar1 and Dexi Liu1 (1) Department of Pharmaceutical and Biomedical Sciences, University…
Critical Path Initiative for Regenerative Medicine in Japan
Fig. 12.1 Risk categories of first–third-class regenerative medicine technologies To implement a plan for the provision of first-class regenerative medicine, the provider is required to submit a plan to the…
Alcoholic Cirrhosis, Transplantation, and Recurrence of Disease
Medical factors Failure of medical therapy Probability of survival without transplant MELD score Pulmonary status Renal failure Infection Surgical factors Probability of survival with transplant Age BMI Technical complexity (anatomic…
Recurrence of Primary Biliary Cirrhosis Following Liver Transplantation
Fig. 5.1 Absolute number of liver transplants for patients with PBC by year [6] 5.3 Survival Following Liver Transplantation for PBC Patient and graft survival for PBC are excellent compared…
Cholangiocarcinoma
Fig. 14.1 Metastatic cholangiocarcinoma to the liver Fig. 14.2 Retroaortic/retrocaval recurrent cholangiocarcinoma Fig. 14.3 Lytic metastases to the (a) iliac bone and (b) spine Fig. 14.4 Pulmonary metastatic cholangiocarcinoma Pathologic…
Recurrence of HCC When Transplanted Outside Milan Criteria
Author/institution Proposed expanded criteria Radiology/path 5-year survival Yao, UCSF [14] 1 nodule ≤6.5 cm, or 2–3 nodules ≤4.5 cm and total tumor diameter ≤8 cm Pathology MC—72 % EC—73 %…
