Response criteria Groups Definition Advantages Disadvantages References Radiologic RECIST Complete response Disappearance – Objective, well-evaluated response measure in solid tumors – Not well established in BRCP and LAPC [12] Partial…
Reference BRPC cases Regiment Number resected (%) R0 resection (%) OS, all pts (mo) OS, resected pts (mo) Turrini [85] 49 5-FU/Cis + XRT 9 b b b Chun [24] 74 5-FU/Gem + XRT…
Fig. 10.1 Development of new drugs and regimens in the treatment of pancreatic cancer. Drugs or regimen activity demonstrated in a phase III study. Not all agents are approved by…
Setting Study Regimen Goal Opened Borderline resectable ALLIANCE A021101 mFFX—no 5FU bolus—4 cycles, then RT/cape; gemcit postop Accrual rate, toxicity, CR/PR, completion of all therapy, R0/R1 March 2013 Pilot study…
Fig. 10.1 Pelvic exenteration Differently to the classic VRAM flap, its variants — the de la Plaza, and Taylor flaps, with a skin island designed differently and higher on the…
Fig. 7.1 Operative view after completion of extended (cylindrical) abdominoperineal resection 7.2 Role of Surgery Obtaining a radical R0 resection is the most important prognostic factor related to improved oncologic…
Study N. of patients Indication (%) Mäkelä et al. [16] 106 9 Bleeker et al. [17] 213 33 Primrose et al. [18] 1202 25 Nakamoto et al. [19] 12 58…
Authors Classification Definition Pilipshen et al. (1984) [15] Anatomic pelvic side involved Anastomotic Perianastomotic Pelvic disease without fixation Pelvic disease with fixation Pelvic disease (with or without fixation) presenting through…
N. Question Type of response 1 How many patients with LRRC were managed within the MDT of your unit in a 24-month period between January 2013 and December 2014? Range…
Reference LR (%) DFS(%) OS (%) Median FU (months) Local excision You et al. [8] 8.2 93 77 60 Bentrem et al. [9] 15.0 93 89 60 Endreseth et…
