Novel Nonbiologic Therapies for Ulcerative Colitis
20. Baumgart DC. Extended colonic release low-molecular weight heparin (LMWH) not ready for use in ulcerative colitis. Evid Based Med. 2011;16:71–2.PubMed 21. Tytgat GN, Van Nueten L, Van De Velde…
Probiotics, Prebiotics, and Antibiotics for Ulcerative Colitis
Author Ref. Maintenance or induction of remission Probiotic Comparator Study duration UC population Primary clinical outcome Results Treatment arm Control arm(s) Tursi et al. [49] Induction of remission VSL#3 + balsalazide Balsalazide…
Beyond Infliximab: Other Anti-TNF Therapies for Ulcerative Colitis
Clinical trials ACT1/ACT2 ULTRA1/ULTRA2 PURSUIT-SC Placebo (n = 121/123) IFX 5 mg/kg (n = 121/121) IFX 10 mg/kg (n = 122/120) Placebo (n = 130/246) ADA 80/40 (n = 130/–) ADA 160/80 (n = 130/248) Placebo (n = 331) GLM 100/50 (n = 72) GLM 200/100…
The Role of the Food and Drug Administration in Medical Therapy for Ulcerative Colitis
Drug FDA approval FDA-approved indication in ulcerative colitis Prednisolone 1972 To tide the patient over a critical period of the disease in ulcerative colitis Sulfasalazine 1977 Treatment of mild to…
Infliximab for Ulcerative Colitis
Fig. 15.1 Mucosal healing 14 weeks after introduction of infliximab. Endoscopic images of the sigmoid at baseline (upper panel) and at week 14 (lower panel) in a patient receiving infliximab…
Tacrolimus, Sirolimus, and Mycophenolate Mofetil
© Springer Science+Business Media New York 2014Gary R. Lichtenstein (ed.)Medical Therapy of Ulcerative Colitis10.1007/978-1-4939-1677-1_14 14. Tacrolimus, Sirolimus, and Mycophenolate Mofetil Andreas Fischer1 and Daniel C. Baumgart1 (1) Department of Medicine, Division of Gastroenterology and Hepatology Charité Medical…
Azathioprine/6-Mercaptopurine Metabolism in Ulcerative Colitis: A Guide to Metabolite Assessment—An Evidence-Based Approach
Fig. 12.1 Azathioprine (AZA) metabolism. XO xanthine oxidase, 6-TU 6-thiouric acid, and 6-TIMP 6-thioinosine monophosphate An apparent genetic polymorphism has been observed in TPMT activity in both the Caucasian and…
Antimetabolite Therapy in Ulcerative Colitis: Azathioprine, 6-Mercaptopurine, and Methotrexate
and Javier P. Gisbert1 (1) Department of Gastroenterology, La Princesa University Hospital, Diego de Leon 62, Madrid, 28006, Spain Javier P. Gisbert Email: javier.p.gisbert@gmail.com KeywordsThiopurinesAzathioprineMercaptopurineMethotrexateUlcerative colitis Introduction Ulcerative colitis (UC) is a…
Contrast and Comparison of Mesalamine Derivatives in the Treatment of Ulcerative Colitis
Fig. 7.1 Proposed metabolic pathway of 5-ASA after oral administration. The shaded area (large intestine) indicates the site of topical action. Unformulated 5-ASA is absorbed rapidly from the small intestine,…
The Importance of Mucosal Healing in Ulcerative Colitis
Fig. 5.1 Variable appearances of mucosa in ulcerative colitis In an effort to quantify the degree of inflammation, a number of different clinical, endoscopic, and composite scoring systems have been…
