Targeted Renal Nerve Deactivation by Neurotropic Agents
Fig. 16.1 Longitudinal sections of the 30 day endpoint histology of the sciatic nerve bundles from animals injected with (a) NW2013 and (b) normal saline Overall, agent NW2013 was determined…
ReCor Medical Paradise® Renal Denervation System
Fig. 9.1 The paradise renal denervation system. (a) Paradise generator. (b) Paradise catheter: ultrasound transducer within cooling balloon. (c) The paradise system in situ (artistic rendering) Paradise Generator The Paradise…
Perivascular Renal Denervation (PVRDTM): Chemical Renal Denervation with Micro-Doses of Ethanol Using the PeregrineTM Renal Denervation Device
Fig. 13.1 Schematic drawings showing sequence of chemical denervation with EtOH. The upper left panel shows the anatomy of the mid-portion of the renal artery and shows no significant organs…
Therapeutic Intra Vascular Ultrasound (TIVUS)
Fig. 10.1 The TIVUS™ System (Console and Multidirectional Catheter) (Printed with permission from Cardiosonic) Fig. 10.2 Fluoroscopic image of the multidirectional TIVUS™ Catheter in the renal artery introduced over a…
NOVOSTE: The Brachytherapy Approach to Renal Denervation
Fig. 12.1 Beta-Cath™ 3.5F system Limitations of RF Ablation Ample data exists to support the concept of renal sympathetic nerve RF ablation for the treatment of resistant hypertension [1, 2]….
Diabetes and Metabolic Syndrome
Fig. 23.1 Sympathetic activity measured by MSNA in normotensive controls (NT), diabetes mellitus type 2 (DM2), hypertension (HTN) and metabolic syndrome (HTN + DM2) (Modified from Huggett et al. [1])…
The Potential Role of Catheter-Based Renal Sympathetic Denervation in Chronic and End-Stage Kidney Disease
Fig. 22.1 Effects of RDN on BP (a) and changes in eGFR (b) over time in Symplicity HTN-1 with follow-up to 2 years (Reproduced from Symplicity HTN-1 Investigators [8], with…
Renal Denervation for Congestive Heart Failure
Fig. 20.1 Interaction of the sympathetic nervous system, kidney and activation of the renin-angiotensin-aldosterone pathway In heart failure, sympathetic stimulation leads to activation of the renin-angiotensin-aldosterone system with increased sodium…
Medtronic Ardian Symplicity™ Renal Denervation Devices
Catheter name Electrode size Ablation time Catheter configuration Guiding catheter F size compatible Arch™ and $$$; Single (2 mm) 2 min/site Non-steerable 8F Flex™ and $$$; Single (2 mm) 2…
Great Myths of Blood Pressure Effect Size in Renal Denervation
Fig. 21.1 Top: The normal distribution of blood pressures from repeated blood pressure measurements in a hypothetical patient presenting to the clinic with a ‘true’ mean blood pressure of 150…
