Drug CrCl 60–46 mL/min CrCl 45–30 mL/min CrCl 29–10 mL/min Dialysis Nephrotoxicity presentation/comments Arsenic trioxide No adjustment needed No adjustment needed Drug exposure may be higher, monitor for toxicity, and lower doses may…
Invitation to assess readiness to have conversation: “Can we talk about how things have been going with your kidney disease?” Using open-ended “big-picture” questions to assess care goals and preferences:…
Cancer type SIR Observed incidence/100,000 person-years Non-Hodgkin lymphoma 7.54 194 Lung 1.97 173 Liver 11.56 120 Kidney 4.65 97 Colorectum 1.24 80.9 Melanoma 2.38 49.2 Thyroid 2.95 30.7 Urinary bladder…
Class Examples Kidney toxicity Antiangiogenic therapy Bevacizumab, sunitinib, sorafenib, pazopanib, everolimus Hypertension, proteinuria, TMA, AKI EGFR inhibitors Cetuximab, erlotinib, gefitinib, lapatinib, panitumumab Hypomagnesemia, hypokalemia Multifunctional TKIs Imatinib, dasatinib, ponatinib, bosutinib…
Fig. 12.1 Thrombotic microangiopathy. The figure showing changes of TMA (a hematoxylin and eosin stain, b periodic acid-Schiff stain) with peripheral capillary wall thickening and focal glomerular basement membrane duplication….
Stage GFR (mL/min/1.73m2) Description 1 90+ Normal kidney function but urine or structural abnormalities 2 60–89 Mildly reduced kidney function 3a 45–59 Moderately reduced kidney function 3b 30–44 4 15–29…
Fig. 10.1 Bidirectional interactions between CKD and RCC For those patients with mild CKD or no evidence of CKD prior to the diagnosis of RCC, the surgical procedure will have…
Fig. 1.1 Causes and syndromes leading to acute kidney injury in cancer patients Prerenal Causes Sepsis and hypoperfusion are commonly reported causal etiologies of AKI in patients with cancer [22,…
(1) Department of Clinical and Molecular Medicine, University of Rome Sapienza St Andrea Hospital, Rome, Italy 1.1 Clinical Case Presentation A 54-year-old, Caucasian male, gardener, presented to the outpatient…
(1) Department of Clinical and Molecular Medicine, University of Rome Sapienza St Andrea Hospital, Rome, Italy 3.1 Clinical Case Presentation A 45-year-old, Caucasian female, postal employee, presented to the…
